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M2Gen Oncology-Focused Bioinformatics Support Services

M2Gen has launched oncology-focused bioinformatics support services. Leveraging the results and knowledge gained from the Orien Avatar Program, an oncology clinic-genomics dataset, M2Gen offers bioinformatics services that include paired tumor and germline whole-exome sequencing (WES) analysis with panels-of-normal filtering; tumor-only WES analysis with virtual-normal somatic mutation classification; and tumor-only RNA sequencing analysis. M2Gen said that pipeline analysis is WES and RNA-seq capture kit-agnostic, and uses the most up-to-date human genome reference and gene build.

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.