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LifeMap TGex Version 3.0

LifeMap Sciences has introduced version 3.0 of its TGex clinical genomics platform, featuring interpretation and analysis for structural variations based on phenotypes. The new release draws on the LifeMap Sciences GeneCards human gene database to "score" structural variations according to a patient's phenotype, then provides evidence to help with interpreting links between the gene and the phenotype and other associations. The GeneCards VarElect next-generation sequencing phenotyper supports genome-wide analysis of both copy-number variations and single-nucleotide variations, TGex said.

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.