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KbioBox Bioinformatics Portal

KBioBox has released the KbioBox bioinformatics portal that includes a “3 click” gene editing off target analysis program and a “3 Click” gene edit biodesign program. The gene edit off target analysis solution identifies off targets in whole genomes while the gene edit design analysis solution provides top ten biodesigns based on input information. Both solutions return simple annotated reports that include intuitive visualizations, locus information, and whole-genome off target analysis for designs.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.