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Integrated DNA Technologies xGen Exome Research Panel

Integrated DNA Technologies has launched the xGen Exome Research Panel for insightful analysis of the human exome via next-generation sequencing. The panel includes a total of 429,826 probes that span 39 Mb of the human genome, providing deep uniform coverage of 19,363 genes. Each probe within the panel is individually synthesized and undergoes a rigorous manufacturing and quality-assessment process in accordance with GMP standards. Missing or truncated probes are identified by mass spectrometry and OD measurements and are eliminated before pooling, providing a unique advantage over array-derived probe pools. The approach selects for full-length probes, enabling highly uniform coverage. Scientists using the xGen Exome Research Panel with xGen Lockdown Reagents and the optimized protocol can now obtain reliable and reproducible exome data in a single day, IDT said in a statement. 

The Scan

Genetic Risk Factors for Hypertension Can Help Identify Those at Risk for Cardiovascular Disease

Genetically predicted high blood pressure risk is also associated with increased cardiovascular disease risk, a new JAMA Cardiology study says.

Circulating Tumor DNA Linked to Post-Treatment Relapse in Breast Cancer

Post-treatment detection of circulating tumor DNA may identify breast cancer patients who are more likely to relapse, a new JCO Precision Oncology study finds.

Genetics Influence Level of Depression Tied to Trauma Exposure, Study Finds

Researchers examine the interplay of trauma, genetics, and major depressive disorder in JAMA Psychiatry.

UCLA Team Reports Cost-Effective Liquid Biopsy Approach for Cancer Detection

The researchers report in Nature Communications that their liquid biopsy approach has high specificity in detecting all- and early-stage cancers.