Integrated DNA Technologies and Aldevron's GMP SpyFi Cas9 Nuclease
Aldevron and Integrated DNA Technologies have released GMP SpyFi Cas9 Nuclease for clinical and commercial applications. SpyFi Cas9 Nuclease, which is the trade name for Aldevron's research grade and GMP products, was developed through a partnership between the two companies. The advantages of SpyFi Cas9 Nuclease include reduced off-target effects combined with clinically relevant on-target activity, Aldevron said. Its release provides researchers and scientists with a consistent product for gene editing programs, from discovery through clinical and commercial manufacturing.
This specific Cas9 protein variant resulted from a substantial amount of development of the wild-type Streptococcus pyogenes Cas9 sequence. This nuclease also functions well in ribonucleoprotein (RNP) delivery format and is compatible with ex vivo gene editing protocols. GMP-grade SpyFi Cas9 Nuclease is available in 1 mg and 10 mg vials.