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Insight Genetics' Insight RET Screen

Insight Genetics has launched Insight RET Screen, a CLIA-validated assay that detects oncogenic RET (rearranged during transfection) expression in non-small cell lung cancer (NSCLC) patients. Chromosomal fusions involving the RET tyrosine kinase gene are driver mutations in papillary thyroid cancer and in approximately 2 percent of lung cancers. In NSCLC, the most frequently observed fusion partner with the RET kinase domain is the KIF5B gene (62 percent) with a smaller fraction fused with the CCDC6 (16 percent) or NCOA4 genes (8 percent). The current standard in diagnostic assay drug-development partnerships has been to use RET fluorescence in situ hybridization (FISH) to identify patients for clinical trial enrollment. Insight Genetics' solution provides results within 48 hours or less and with minimal tissue requirement. In a head-to-head comparison to a RET FISH assay, the Insight RET Screen identified 67 percent more patients who were RET fusion-positive. The Insight RET Screen complements the portfolio of assays currently offered by Insight Molecular Labs that detect targetable mutations including ALK, ROS1, EGFR, KRAS, and BRAF.

The Scan

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Researchers in Scientific Reports find that the makeup of brown bears' gut microbiomes allows them to reach similar sizes even when feasting on different foods.

Finding Safe Harbor in the Human Genome

In Genome Biology, researchers present a new approach to identify genomic safe harbors where transgenes can be expressed without affecting host cell function.

New Data Point to Nuanced Relationship Between Major Depression, Bipolar Disorder

Lund University researchers in JAMA Psychiatry uncover overlapping genetic liabilities for major depression and bipolar disorder.