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Indigo Biosciences Gene Expression Assay Kit

Dec 11, 2018

Indigo has launched a gene expression assay kit featuring optimized "Upcyte" hepatocytes, which are human donor-derived liver cells established by Upcyte Technologies. The kit provides optimized reagents for culturing and treatment of Upcyte hepatocytes to examine drug-induced changes in the expression of seven clinically relevant cytochrome P450 enzymes. According to the firm, the hepatocytes combine the advantages of primary hepatocytes with the added practical advantage of having access to the same donor cells for use in iterative, large-scale testing over extended periods.

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Feb 19, 2020

Covaris Viral RNA Extraction Kits

Covaris has launched two new kits for viral RNA extraction from nasal or throat swab sample collection devices. The truXTRAC Viral RNA Extraction kit uses Puritan swabs and contains all components for the firm's Adaptive Focused Acoustics-based extraction as well as magnetic bead-based purification of high-quality RNA from synthetic swabs. The truXTRAC-PCR Direct Viral RNA Extraction kit can be used directly in real time RT-PCR assays without prior purification, provided an internal control is included.

Feb 19, 2020

Integrated DNA Technologies xGen Prism DNA Library Prep Kit

Integrated DNA Technologies (IDT), a Danaher company, has launched the xGen Prism DNA Library Prep Kit, which is designed for challenging and low-quality samples. The kit can convert cell-free DNA and DNA from formalin-fixed paraffin-embedded tissue into high-quality next-gen sequencing libraries. It greatly reduces adapter dimers and uses unique molecular identifiers (UMIs) for enhanced error correction.

Feb 18, 2020

Thermo Fisher Scientific Applied Biosystems PowerTrack SYBR Green PCR Master Mix

Thermo Fisher Scientific has released the Applied Biosystems PowerTrack SYBR Green PCR Master Mix. It is designed for real-time PCR workflows and is compatible with all qPCR instruments. It contains a two-color tracking dye system to help researchers keep track of where they have pipetted. The mix uses an antibody-mediated hot-start mechanism to control activation of the Taq enzyme. It also includes UNG and dUTP enzymes to prevents previously amplified PCR products from contaminating subsequent qPCR reactions. The mix provides results ranging from 0.1 pg to 100 ng of complementary DNA per reaction and can be used in standard or fast cycling mode.

Feb 18, 2020

Nebula Genomics: 30X Whole-Genome Sequencing Service

Nebula Genomics has launched a new, direct-to-consumer whole-genome sequencing service. Performed with MGI DNBSEQ T-Series instruments in BGI's global network of sequencing centers, Nebula's service offers 30X coverage for $299.

Individuals who sequence their genome through Nebula will retain full control of their genomic data, the firm added in a statement.

Feb 13, 2020

PerkinElmer: Sciclone G3 NGSx HT Workstation

PerkinElmer has launched the Sciclone G3 NGSx HT Workstation for automated next-generation sequencing library preparation. The instrument comes with a 384-plex low-volume pipetting head, on-deck thermal elements, a shaker, a thermal cycler, and a robotic pipette tip loader. It can automate cDNA synthesis from RNA or single cells as well as library construction from cDNA or gDNA. DNA-seq libraries can be prepared using the Nextflex Rapid XP DNA-seq kit.

Feb 11, 2020

Living DNA: African Ancestry DNA Test Report

Living DNA, a direct-to-consumer genealogy DNA service, has launched an African ancestry DNA test report that covers 72 regions in Africa. Living DNA said that its report offer five times the African ancestry coverage of any other test, and has been specially designed for African Americans and African Europeans who are researching their roots. The test combines recent ancestry breakdown (last 1,000 years) with deep direct maternal and paternal histories, as well as rich information about the regions from which customers' ancestors originate, covering geography, languages, traditions, and culture. All existing customers with African ancestry can log into their results platform and choose to update their results free of charge, the company said. New customers can purchase a test on offer for Black History Month for $79.

Feb 07, 2020

CDI Labs HuScan and VirScan

CDI Laboratories' Antygen Division, which provides contract research for R&D in the therapeutic and diagnostic space, has launched two biomarker discovery assays, HuScan and VirScan. HuScan detects antibodies against the entire human proteome via long peptides on the surface of bacteriophages, antibody pulldown, and sequencing readouts. VirScan detect antibodies against the proteomes of every viral strain known to infect humans in the same manner. Both assays represent the first commercial use of PhIP-seq technology, the company said.

Feb 06, 2020

CeGaT Exome Xtra

CeGaT has launched the CeGaT Exome Xtra test, which the firm says increases the diagnostic yield compared to a standard exome test. Besides coding sequences, it includes all medically relevant regions throughout the genome, such as pathogenic and likely pathogenic intronic variants, disease-associated transcripts, cryptic exons, as well as the mitochondrial genome. In addition, the data analysis considers variants in genes with reduced penetrance, variable expressivity, imprinting effects, and SNV/CNV combinations.

Feb 06, 2020

Thermo Fisher Scientific Ion Torrent CarrierSeq ECS Kit

Thermo Fisher Scientific has introduced the Ion Torrent CarrierSeq ECS Kit for expanded carrier screening. The AmpliSeq-based panel, which runs on the Ion GeneStudio S5 sequencer, covers 420 genes, including difficult-to-sequence ones like SMN1 and SMN2 for spinal muscular atrophy, GBA for Gaucher disease, CYP21A2 for 21-hydroxylase deficient congenital adrenal hyperplasia, and HBA1 and HBA2 for alpha thalassemia. It detects more than 28,000 non-benign ClinVar variants, including single nucleotide variants and copy number variants, and comes with customizable Carrier Reporter software.

Feb 05, 2020

Hologic Panther Scalable Solutions

Hologic launched new products in the US and Europe within its Panther Scalable Solutions portfolio, in which the firm's molecular diagnostic Panther system functions as the foundation for optional add-ons. The add-on components include Panther Fusion, which launched in 2016 and provides additional IVD menu and an Open Access functionality; Panther Plus and Panther Link, which are now available; and Panther Trax, which is in development.

With Panther Plus, labs can load more consumables directly on the instrument, allowing up to 13.5 consecutive hours of walk-away time. Panther Link is a software solution that provides additional efficiencies by creating a virtual connection that allows multiple Panther instruments to communicate with one another and function within a singular, streamlined workflow. Panther Trax is being developed to physically and electronically link multiple Panther instruments into a single workcell.

Feb 05, 2020

Bio-Techne Next-Generation ELISA Kits

Bio-Techne has launched its Quantikine QuicKit next-generation ELISA product line, which expands the capabilities of its legacy Quantikine ELISA kits. According to Bio-Techne, the kit enables researchers to accomplish more in their day without compromising quality. It enables quantitation of proteins in serum, plasma, and cell supernates in 90 minutes.

Jan 29, 2020

NIPD Genetics Veragene

NIPD Genetics has expanded its Veragene noninvasive prenatal test. The new version of the assay, which covers aneuploidies, microdeletions, and monogenic diseases, is able to identify 2,000 mutations in 99 genes involved in 100 monogenic autosomal recessive and X-linked disorders.  

Jan 27, 2020

Swift Biosciences, Opentrons Labworks Automated 2S Turbo DNA Library Preparation

Swift Biosciences and Opentrons Labworks have launched pre-scripted, automated protocols for the Swift 2S Turbo DNA library preparation kit on the Opentrons OT-2 liquid handler. The protocol can be combined with the Swift Deceleration Module to obtain longer fragments of 550 bp, control fragmentation time on automation platforms, or adjust sample elution buffer.

Jan 27, 2020

Agilent SureSelect XT HS2 DNA Kit

Agilent Technologies has launched its SureSelect XT HS2 DNA kit, which it said will offer researchers a complete solution to choose workflow options. The firm said the kit allows users to multiplex hundreds of samples in one sequencing run, remove sample contamination by indexing from reads, and improve error correction to detect variants with low allele frequencies. 

Jan 27, 2020

Qiagen QCI Precision Insights

Qiagen has launched Qiagen QCI Precision Insights in Europe. QCI Precision Insights is a clinical interpretation service provided by a team of molecular biologists and oncologists who translate patient-specific molecular data into clinical insights and therapeutic options. The new offering includes European Society for Medical Oncology (ESMO) guidelines and the European Medicines Agency (EMA)-approved oncology drugs catalog. Qiagen said that the service enables molecular pathologists and oncologists in Europe to confidently match complex genomic test data to relevant, geographically matched treatment options in minutes for evidence-based, individualized treatment recommendations.

At the Lancet, more than two dozen public health researchers condemn the conspiracy theories that have emerged surrounding the source of the COVID-19 outbreak.

The Washington Post reports that Philip Leder, who helped uncover how DNA codes for proteins and studied the role of genes in cancer, has died.

Researchers from Trinity College Dublin and the University of Pittsburgh look into how often de novo genes arise and how important they may be.

In Nucleic Acids Research this week: pipeline for genotyping Alu retrotransposon mobile element insertions, previously undocumented non-coding RNAs, and more.