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IncellDx PD-L1 Assay

IncellDx has released a new single-cell PD-L1 assay for research use only. The new "OncoTect iO Quantitative" test kit includes labeled antibodies to PD-L1 and CD45, CD8, and CD3 cell subsets as well as a DNA dye for cell cycle and quantitative detection of PD-L1 expression in non-small cell lung cancer tissue. According to the company, kits can be used on numerous samples types including FNA, core biopsies, and blood. The assay is also applicable to tumor types other than NSCLC including lung, bladder, and head and neck cancers.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.