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IncellDx BioINK PD-L1 CTC Core Kit

IncellDx has launched its BioINK PD-L1 CTC Core Kit, a complete, pre-optimized tool to identify, enumerate, and quantify PD-L1 expression in circulating tumor cells. According to the firm, the kit includes the addition of a separate quantitative control cell cocktail — called OncoTect iO Control Cells — that combines PD-L1 positive epithelial cells, PD-L1 negative epithelial cells, and peripheral blood mononuclear cells. The tool allows labs to assess linearity and lower limits of detection for CTC enumeration with known quantities of cells in a lyophilized standard.

The firm's BioINK technology enables highly sensitive and specific quantification of protein or mRNA expression at a single-cell-by-cell resolution optimized for microfluidic chips. 

The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.