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Illumina Infinium Global Diversity Array

Illumina has launched the Infinium Global Diversity Array, the commercial version of the array designed for use in the National Institutes of Health All of Us research program. The array features about 1.9 million variants, including imputation-optimized tag SNPs and up-to-date clinical research content from public databases such as ClinVar, the National Human Genome Research Institute-EBI database, and Pharmacogenomics Knowledgebase (PharmGKB). The array has broad utility for a variety of large-scale screening and association studies, with content relevant for polygenic risk scoring, common-disease association studies, and inherited risk screening, Illumina said. In addition, the array offers extremely high genomic coverage and imputation performance across 26 diverse populations. It comes in an eight-sample format chip that has room to add up to 175,000 custom beadtypes, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.