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IDT rhAmpSeq Targeted Sequencing System

Integrated DNA Technologies (IDT) has launched the rhAmpSeq targeted sequencing system. The proprietary rhAmpSeq chemistry enables highly multiplexed target amplification for sequencing on Illumina platforms with high on-target rates and uniform coverage. Its applications include human disease research, sample tracking and analysis, CRISPR genome editing analysis, and agricultural biotechnology. The system makes use of IDT's RNase H2 PCR technology, employing an RNase H2/DNA polymerase enzyme system coupled with RNA-DNA hybrid primers. It has been optimized for panel sizes from tens to thousands of amplicons in a single reaction.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.