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HTG Molecular EdgeSeq Reveal

Jan 16, 2019

HTG Molecular today launched its HTG EdgeSeq Reveal software. According to the firm, the software streamlines biomarker data analysis from samples analyzed with the HTG EdgeSeq Precision Immuno-Oncology Panel on its EdgeSeq system. When used with the panel, the software allows applications including immunophenotyping of tumor infiltration lymphocytes, monitoring of immunotherapy response biomarkers, and elucidating immune-escape mechanisms know to drive disease progression. The firm noted that users will be able to conduct molecular profiling using a wide variety of sample types, potentially allowing them to support translational applications and determine potential biomarkers for companion diagnostic development. 

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Aug 11, 2020

Centogene CentoMD 5.8

Centogene has released an update to its curated rare disease mutation database, CentoMD 5.8. This latest version includes more than 12.7 million unique variants, greater than 81,000 classified and curated variants, and over 199,000 individuals linked to HPO terms. Since December 2019, the number of cases in CentoMD has grown to more than 430,000, covering more than 120 countries.

Aug 07, 2020

Illumina NovaSeq 6000 v1.5 Reagent Kit

Illumina has launched a new NovaSeq 6000 reagent kit that the company said could reduce sequencing costs for a human genome to $600.

The v1.5 kit offers improved quality, with an average Q30 score above 85 percent for read lengths up to 2x150 bp. Additional cycles per kit enables full support for unique molecular identifiers. The kits also double shelf life — up to six months — and are compatible with the new Illumina DNA PCR-Free Prep kit.

Aug 07, 2020

NIST: SARS-CoV-2 Synthetic Gene Fragments

Researchers at the National Institute of Standards and Technology have produced synthetic gene fragments from SARS-CoV-2. Shipped in vials with a data sheet listing the concentration of fragments in the solution, the RNA fragments can be used to measure the sensitivity of tests for the coronavirus. They can also use the synthetic RNA to develop more sensitive tests or new kinds of tests, NIST said. Each solution contains about 1 million copies per microliter. NIST is releasing the synthetic RNA as a research grade test material while it expects to further develop it as a standard reference material. The material is free to researchers, test manufacturers, and testing labs. Technical information and instructions for requesting the material are available here.

Aug 06, 2020

GeneDx GenomeXpress

GeneDx, a subsidiary of BioReference Laboratories/Opko Health, has launched GenomeXpress, a rapid genome sequencing test. GenomeXpress includes both protein-coding and non-coding regions of the genome including promoter, intronic, and untranslated regions, enabling the detection of characterized/pathogenic variants in regions that are not assessed by exome sequencing. The company delivers a written report for all confirmed variants in known disease-causing genes to the ordering healthcare provider within approximately seven days after testing. It also provides a written report for all confirmed variants within approximately 14 days after the start of testing. 

Aug 04, 2020

Horizon Discovery Single Cell RNAseq-Linked CRISPR Screening Service

Horizon Discovery has added single cell RNAseq-linked pooled CRISPR screening to its CRISPR screening services portfolio. Coupling pooled CRISPR screening to single cell RNAseq allows the impact of CRISPR-based gene modification to be examined on a global transcriptomic scale at single cell resolution. The platform offers high-quality screening data and biological insight to address gaps in target identification and validation by integrating the effect of gene editing with complex gene expression mapping, the company said. 

Aug 04, 2020

Adaptive Biotechnologies ImmunoSeq T-Map COVID Service

Adaptive Biotechnologies has launched the immunoSeq T-Map COVID, a proprietary research product and data-analysis service to measure the T cell immune response to vaccines in development and track the persistence of that response over time.

The product leverages data from more than 1,000 patients to provide researchers with a quantitative map of T cell receptors and SARS-CoV-2 antigens that elicit an immune response. These data will be available through Adaptive's cloud-based immunoSeq Analyzer and is powered by ImmuneCode, an open database developed in partnership with Microsoft.

Aug 03, 2020

Cytek Biosciences cFluor Reagents

Flow cytometry firm Cytek Biosciences announced the launch cFluor reagents, short for "Cytek Fluorochrome," that are validated on the firm's Aurora and Northern Lights full spectrum cell analysis systems. The first batch of reagents includes cFluor YG584, cFluor B548, and cFluor R710 and allows users to reveal more from the full spectrum panel with a new option excitable by the yellow-green, blue, and red lasers respectively. Other dyes are coming soon, the firm said. 

Aug 03, 2020

Personalis NeXT Liquid Biopsy

Personalis has launched NeXT Liquid Biopsy, an exome-scale blood-based tumor-profiling assay for advanced-stage solid tumor cancer patients. According to the company, the test monitors over 20 times more genes than most targeted liquid biopsy panels on the market. Personalis believes its more comprehensive option can help biopharmaceutical companies advance their understanding of tumor biology, including resistance mechanisms, to aid in the development of next-generation cancer therapies. 
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Myriad Genetics Amplify for Fetal Cell-Free DNA Sequencing

Myriad Genetics has launched Amplify, which sequences the fetal cell-free DNA fragments circulating in a mother's blood and increases the fetal fraction in a sample for non-invasive prenatal screening. The company is hoping that the technology will improve the performance of its Prequel NIPS test. The analytical validation of Amplify involved samples from more than 1,000 women and showed that the fetal fraction was 2.3 times greater on average compared to standard NIPS. The improvement reduces false positive and false negative results, including for common aneuploidies, expanded aneuploidies, microdeletions, and a baby's sex, Myriad noted. The company also said that the technology will reduce the number of sampels that fail to produce a result due to low fetal fraction and deliver results to 99.9 percent of patients. 

Jul 30, 2020

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Diagenode, a firm providing epigenomics services and library prep products, has announced a new bulk 3' mRNA sequencing service, developed in collaboration with Alithea Genomics.

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Jul 29, 2020

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HTG Molecular Diagnostics has launched its HTG EdgeSeq Pan B-Cell Lymphoma Panel, which the firm said is designed to provide molecular characteriation of aggressive, indolent, and rare lymphomas. The research-use-only panel enables investigators to measure the expression of about 300 genes linked to the lymphoma transcriptome. The panel is available in kit form or as a service at HTG's VERI/O laboratory. 

Jul 28, 2020

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Twist Bioscience is offering two new SARS-CoV-2 antibody panels for research use only.

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Jul 22, 2020

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Twist Bioscience has added 16 new synthetic controls for common respiratory viruses with symptoms similar to COVID-19, including influenza H1N1, influenza H32N, influenza B, rhinovirus, enterovirus, and several human coronaviruses including a prevalent mutated strain of SARS-CoV-2 (D614G.)

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Jul 17, 2020

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A new analysis suggests warming, not the arrival of humans, led to the extinction of the woolly rhinoceros thousands of years ago, the Economist reports.

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