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Horizon Discovery's Synthetic Plasma cfDNA Reference Standard

Horizon Discovery Group has launched a new tool called the HDx cell-free DNA Reference Standard in Synthetic Plasma. According to the company, the new reference set addresses challenges in extracting DNA for liquid biopsy testing, helps to ensure that an assay is not over or under loaded, and allows users to better control variation in their tests. The set contains eight cancer-relevant mutations including BRAF, EGFR, KRAS, NRAS, and PIK3CA at 5 percent, 1 percent, and 0.1 percent allelic frequencies. Because the reference is engineered in plasma, mimicking actual human material, users can gain better understanding of assay performance from extraction and quantification through to analysis and informatics, Horizon added.

The Scan

Team Tracks Down Potential Blood Plasma Markers Linked to Heart Failure in Atrial Fibrillation Patients

Researchers in BMC Genomics found 10 differentially expressed proteins or metabolites that marked atrial fibrillation with heart failure cases.

Study Points to Synonymous Mutation Effects on E. Coli Enzyme Activity

Researchers in Nature Chemistry saw signs of enzyme activity shifts in the presence of synonymous mutations in a multiscale modeling analysis of three Escherichia coli genes.

Team Outlines Paternal Sample-Free Single-Gene Approach for Non-Invasive Prenatal Screening

With data for nearly 9,200 pregnant individuals, researchers in Genetics in Medicine demonstrate the feasibility of their carrier screening and reflex single-gene non-invasive prenatal screening approach.

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.