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Horizon Discovery EGFR Multiplex cfDNA Reference Standard

Horizon Discovery has launched a new cell line-derived EGFR Multiplex cell-free DNA reference standard, which allows labs and assay developers to optimize, validate and routinely monitor performance of PCR assays, NGS tests, and other novel liquid biopsy tests designed to detect EGFR mutations in cfDNA.

The new referene standard covers ten of the most clinically relevant mutations that predict responsiveness to EGFR tyrosine kinase inhibitors, including T790M, L858R, C797S and E746-A750del. Additionally, variants have been carefully selected to represent a mix of different mutation types that can be challenging for laboratories to detect.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.