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Horizon Discovery Edit-R CRISPRa crRNA Libraries

Horizon Discovery announced the introduction of its Edit-R CRISPR arrayed crRNA (CRISPR RNA) libraries, which offer a tool for drug discovery, pathway analysis and disease progression studies. The libraries allow one-gene-per-well investigation by using high-content assays. The Edit-R CRISPRa portfolio also includes catalogue libraries for human and mouse gene families, including ubiquitin enzymes, transcription factors, and kinases, in addition to druggable gene targets and the whole human genome. The firm also noted that researchers will also be able to use bespoke collections to target a specialized gene target list.  

The Scan

Cell Signaling Pathway Identified as Metastasis Suppressor

A new study in Nature homes in on the STING pathway as a suppressor of metastasis in a mouse model of lung cancer.

Using Bees to Gain Insights into Urban Microbiomes

As bees buzz around, they pick up debris that provides insight into the metagenome of their surroundings, researchers report in Environmental Microbiome.

Age, Genetic Risk Tied to Blood Lipid Changes in New Study

A study appearing in JAMA Network Open suggests strategies to address high lipid levels should focus on individuals with high genetic risk and at specific ages.

Study Examines Insights Gained by Adjunct Trio RNA Sequencing in Complex Pediatric Disease Cases

Researchers in AJHG explore the diagnostic utility of adding parent-child RNA-seq to genome sequencing in dozens of families with complex, undiagnosed genetic disease.