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Horizon Discovery Edit-R CRISPRa Arrayed CRISPR RNA Libraries

Horizon Discovery has released the Edit-R CRISPRa arrayed crRNA (CRISPR RNA) libraries, the newest addition to its CRISPR activation reagent platform from the recently acquired Dharmacon business. The new libraries can be used for drug discovery, pathway analysis, and disease progression studies, Horizon said. Edit-R synthetic crRNA arrayed libraries enable one-gene-per-well investigation. They also trigger the endogenous gene's expression, transcribing the gene in its native form.

The Edit-R CRISPRa portfolio includes catalogue libraries for popular human and mouse gene families, such as ubiquitin enzymes, transcription factors, and kinases, in addition to druggable gene targets and the whole human genome. Bespoke collections are also available to support researchers working with a specialized gene target list.

The Scan

Tens of Millions Saved

The Associated Press writes that vaccines against COVID-19 saved an estimated 20 million lives in their first year.

Supersized Bacterium

NPR reports that researchers have found and characterized a bacterium that is visible to the naked eye.

Also Subvariants

Moderna says its bivalent SARS-CoV-2 vaccine leads to a strong immune response against Omicron subvariants, the Wall Street Journal reports.

Science Papers Present Gene-Edited Mouse Models of Liver Cancer, Hürthle Cell Carcinoma Analysis

In Science this week: a collection of mouse models of primary liver cancer, and more.