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Horizon Discovery Edit-R CRISPRa Arrayed CRISPR RNA Libraries

Horizon Discovery has released the Edit-R CRISPRa arrayed crRNA (CRISPR RNA) libraries, the newest addition to its CRISPR activation reagent platform from the recently acquired Dharmacon business. The new libraries can be used for drug discovery, pathway analysis, and disease progression studies, Horizon said. Edit-R synthetic crRNA arrayed libraries enable one-gene-per-well investigation. They also trigger the endogenous gene's expression, transcribing the gene in its native form.

The Edit-R CRISPRa portfolio includes catalogue libraries for popular human and mouse gene families, such as ubiquitin enzymes, transcription factors, and kinases, in addition to druggable gene targets and the whole human genome. Bespoke collections are also available to support researchers working with a specialized gene target list.

The Scan

Another Resignation

According to the Wall Street Journal, a third advisory panel member has resigned following the US Food and Drug Administration's approval of an Alzheimer's disease drug.

Novavax Finds Its Vaccine Effective

Reuters reports Novavax's SARS-CoV-2 vaccine is more than 90 percent effective in preventing COVID-19.

Can't Be Used

The US Food and Drug Administration says millions of vaccine doses made at an embattled manufacturing facility cannot be used, the New York Times reports.

PLOS Papers on Frozen Shoulder GWAS, Epstein-Barr Effects on Immune Cell Epigenetics, More

In PLOS this week: genome-wide association study of frozen shoulder, epigenetic patterns of Epstein-Barr-infected B lymphocyte cells, and more.