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Horizon Discovery CRISPRi and CRISPRa Screening Services

Horizon Discovery announced that it has expanded its functional genomic screening portfolio to include CRISPRi (interference) and CRISPRa (activation) screening services. Horizon's CRISPRi/CRISPRa screening platform substantially broadens the range of possible studies through the capacity to reduce or increase, rather than completely eliminating gene expression, the company said. This enables customers to address critical gaps in target ID and validation as they work to develop novel and more effective drug therapies. The screening capabilities are based on the company's highly optimised CRISPR knockout screening platform. Horizon has also developed an enhanced solution that combines both CRISPRi and CRISPRa screening. This combined solution can reveal 'switch'-like genes that display opposing effects when activated or inhibited in the presence of the drug of interest.

The Scan

Guidelines for Ancient DNA Work

More than two dozen researchers have developed new ethical guidelines for conducting ancient DNA research, which they present in Nature.

And Cleared

A UK regulator has cleared former UK Prime Minister David Cameron in concerns he should have registered as a consultant-lobbyist for his work with Illumina, according to the Financial Times.

Suit Over Allegations

The Boston Globe reports that David Sabatini, who was placed on leave from MIT after allegations of sexual harassment, is suing his accuser, the Whitehead Institute, and the institute's director.

Nature Papers on Esophageal Cancer, Origin of Modern Horses, Exome Sequencing of UK Biobank Participants

In Nature this week: genetic and environmental influences of esophageal cancer, domestic horse origin traced to Western Eurasian steppes, and more.