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Hologic Panther Scalable Solutions

Feb 05, 2020

Hologic launched new products in the US and Europe within its Panther Scalable Solutions portfolio, in which the firm's molecular diagnostic Panther system functions as the foundation for optional add-ons. The add-on components include Panther Fusion, which launched in 2016 and provides additional IVD menu and an Open Access functionality; Panther Plus and Panther Link, which are now available; and Panther Trax, which is in development.

With Panther Plus, labs can load more consumables directly on the instrument, allowing up to 13.5 consecutive hours of walk-away time. Panther Link is a software solution that provides additional efficiencies by creating a virtual connection that allows multiple Panther instruments to communicate with one another and function within a singular, streamlined workflow. Panther Trax is being developed to physically and electronically link multiple Panther instruments into a single workcell.

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Nov 20, 2020

DNAStar Lasergene 17.2 Software

DNAStar has released Lasergene 17.2 software for DNA, RNA, and protein sequencing assembly and analysis. In the latest release, DNAStar has fully integrated the SeqMan NGen application into SeqMan Ultra, greatly improving the workflow for both Sanger and next-generation sequencing analysis.

Users performing sequence assemblies can now go from project setup to finished assembly in one application. For users working with Sanger sequencing data, the new software offers improvements such as the ability to preview and trim trace data prior to assembly; better access to a built-in vector trimming database; and the ability to easily export an image of the assembly for collaboration or publication.

For those doing NGS assembly, the new version includes an updated variant annotation database to enrich the analysis of variants detected in human resequencing data. These updates include dbNSFP version 4.1, new allele and gene frequencies, and a new integration with Mastermind, a database of genomic literature from Genomenon.

Nov 19, 2020

Twist Bioscience RUO SARS-CoV-2 NGS Assay, Biotia COVID-Dx Software

Twist Bioscience has launched its research use-only SARS-CoV-2 next-generation sequencing assay.

The capture-based assay is for detection, characterization, and environmental monitoring of the virus from nasopharyngeal, oropharyngeal, anterior nasal, and mid-turbinate nasal swabs, as well as nasopharyngeal wash/aspirates, nasal aspirates, and bronchoalveolar lavage specimens. It was validated on Illumina's NextSeq platform and includes Twist's synthetic SARS-CoV-2 RNA controls. The limit of detection is 800 viral copies/ml.

The test comes with COVID-Dx comprehensive data analysis software from Biotia, which provides an RUO report on the presence or absence of SARS-CoV-2 virus, the full sequence of the virus, genetic variants, and phylogenetic analysis.

Nov 17, 2020

GeneMatters Automation for Pioneer Telegenetics Platform and RISE Patient Engagement Tools

GeneMatters has added automation features to its Pioneer Telegenetics Platform and has launched RISE Patient Engagement Tools to support patients undergoing genetic testing and counseling.

The Pioneer Telegenetics Platform, available since 2017, is designed to integrate telehealth genetic counseling service delivery and patient management. The platform now includes several automation features designed to reduce administrative burden, provide real-time communication, and allow GeneMatters to quickly deploy custom workflows to meet partner needs.

The RISE (Reach, Inform, Support, and Educate) Patient Engagement Tools specifically support patients and can be used independently or as a complement to Pioneer, and will include modules for genetic care such as scheduling, patient triage, patient education, and results delivery.

Nov 17, 2020

NuProbe Augury

NuProbe has launched an early-access program for its "Augury" platform, an automated design product for customized liquid biopsy NGS panels. Based on proprietary sequence-design algorithms, Augury procedurally generates NGS panels for cell-free DNA analysis, covering the entire coding regions of between one and 30 genes of interest. 

According to the company, these panels typically detect mutations down to 0.2 percent variant allele frequency, and copy number variations down to 4 percent tumor fraction, using 10 to 20 ng of cell-free DNA input. Users can choose to build panels that either cover the full coding regions of the genes of interest, or select hotspot loci. NuProbe expects typical panels to be designed within two days and analytically validated within 12 weeks.

Nov 16, 2020

Twist Bioscience Comprehensive Viral Research Panel

Twist Bioscience has released the Twist Comprehensive Viral Research Panel, a next-generation sequencing-based, research-use only assay that includes 3,153 viral genomes and enables identification of new and divergent viral species. The product uses over a million unique probes targeting sequences compiled from RefSeq, FluDB, and VIPRdb, representing all viral families containing at least one virus known to infect humans.

The panel covers all viral types: single- and double-stranded DNA and RNA genomes. It detects viral co-infections and can be used for metagenomic surveillance applications in stool samples.

The panel will be bundled with analysis software from One Codex.

Nov 12, 2020

Illumina NextSeq 1000, P3 Reagent Kit for NextSeq 2000

Illumina's mid-throughput NextSeq 1000 sequencing system is now commercially available. The instrument offers 400 million reads per run and is more affordable than the NextSeq 2000. It has onboard informatics for rapid secondary analysis.

Illumina has also launched the P3 reagent kit for its NextSeq 2000 sequencing system. The high-output flow cell offers 1.1 billion reads per run, more than three times more than previously available on Illumina's mid-throughput systems. The kit will be available in four configurations: the 100-cycle kit delivers 110 Gb per run; the 200-cycle kit, 220 Gb; and the 300-cycle kit, 330 Gb. A 50-cycle kit is also available for infectious disease, small RNA, and spatial transcriptomics applications.

Nov 12, 2020

MRC Holland: SALSA digitalMLPA

MRC Holland has released SALSA digitalMLPA, a novel technique that enables the simultaneous detection of up to 1,000 copy number variants. It combines MRC Holland's proprietary Multiplex Ligation-dependent Probe Amplification (MLPA) technology for target amplification with next-generation sequencing, using the company's Coffalyser digital MLPA analysis software. Up to 192, and soon up to 384, digitalMLPA samples can be analyzed in parallel. The first digitalMLPA assay available is D001 Hereditary Cancer Panel 1, which targets 28 genes associated with various hereditary cancers.

Nov 11, 2020

IsoPlexis IsoSpark, IsoSpark Duo Systems

IsoPlexis has launched its IsoSpark and IsoSpark Duo systems for functional proteomics. The IsoSpark has an 18-inch footprint and a 4-chip capacity, while the IsoSpark Duo has a 8-chip capacity to allow users to simultaneously run two chip families. The firm said that both systems are fully compatible with its suite of IsoPlexis applications. The systems are available for pre-order, with shipping planned for January 2021. 

Nov 10, 2020

Newomics Microflow-nanospray Electrospray Ionization (MnESI) Source

Newomics has launched the Microflow-nanospray Electrospray Ionization (MnESI) Source for the analysis of antibodies, proteins, nucleic acids, and lipids derived from cells and human plasma. The MnESI Source, which the company comarkets with Thermo Fisher Scientific, delivers small amounts of sample to Newomics M3 multi-nozzle emitters, which are coupled with Thermo Scientific Orbitrap mass spectrometers. The source is designed to effectively ionize and introduce oligonucleotides, protein complexes, and viral particles under native conditions.

Nov 10, 2020

Streck Zulu RT qPCR Instrument

Streck has launched the Zulu RT, a rapid, modular qPCR instrument capable of simultaneously performing four independent experiments. The instrument uses proprietary thermal technology (ramp speeds of 15° C/second for heating and 12° C/second cooling) and powerful optics that enable it to perform a 40-cycle, six-channel, three-step real-time PCR protocol in less than 20 minutes for volumes from 10 µL to 50 µL. The system's modularity allows multiple users at once, in essence acting as four individual thermal cyclers in one, Streck said.

Nov 10, 2020

New England Biolabs: Monarch HMW DNA Extraction Kits

New England Biolabs has released two high molecular weight (HMW) DNA extraction kits. Both the Monarch HMW DNA Extraction Kit for Cells & Blood and the Monarch HMW DNA Extraction Kit for Tissue utilize a novel glass bead-based technology that allows for more efficient and cost-effective extraction. They can extract DNA up to several megabases in size from cells, blood, tissue, or bacteria, with workflows that range from 30 minutes to 90 minutes in duration. The extracted DNA can be used in downstream applications such as long-read sequencing, optical mapping, and linked-read genome assembly. The new kits complement the company's Monarch Genomics DNA Purification Kit and can be used alongside its NEBNext Companion Module for Oxford Nanopore Technologies Ligation Sequencing kit.

Nov 10, 2020

NIPD Genetics: Amfira PGT

NIPD Genetics has launched Amfira PGT, a preimplantation genetic test to detect genetic abnormalities in embryos. The test consists of two panels, the PGT-A panel for aneuploidies for individuals or couples undergoing in vitro fertilization, and the PGT-SR panel for structural rearrangements for couples diagnosed with a structural rearrangement. Both panels can detect selected male polyploidies, as well as deletions and duplications larger than 10 megabases. The turnaround time is five to seven days from sample receipt.

Nov 09, 2020

NanoString Technologies GeoMx DSP Protein Assays for NGS

NanoString Technologies has launched its GeoMx DSP Protein assays for next-generation sequencing readout.

The assays expand the multiplex detection capabilities of GeoMx digital spatial profiling from tens to hundreds of proteins and include more than 50 targets for immuno-oncology applications. The assays also provide complementary protein content for the GeoMx Cancer Transcriptome Atlas panel.

The firm said it has tested performance on both formalin-fixed, paraffin-embedded and fresh frozen tissue samples.

The products are available immediately through NanoString's technology access program.

Nov 06, 2020

Bio-Rad: StarBright Dyes

Bio-Rad has launched three new dyes for flow cytometry in its StarBright line. StarBright Blue 700, StarBright Violet 440, and StarBright Violet 610 consist of fluorescent nanoparticles conjugated to flow antibodies. The dyes offer narrow excitation and emission profiles for improved resolution in flow cytometry experiments. They are also resistant to photobleaching and highly stable, with minimal lot-to-lot variation, according to Bio-Rad, which enables researchers to achieve consistent and reproducible staining. The dyes work with all common staining buffers for easy integration into multicolor panels and the chemistry is designed to ensure no loss of signal in fixation.

Nov 04, 2020

MyNeo ImmunoEngine

Precision oncology company MyNeo has released a new version of its ImmunoEngine bioinformatics platform. The update incorporates two new machine-learning algorithms, NeoMS, a transformer-based predictor based on major histocompatibility complex (MHC) ligandomic data, and NeoIM, a random-forest classifier trained to classify short peptides as either immunogenic or nonimmunogenic. The Belgian firm specializes in identifying and validating precision cancer therapies.

Russia says its candidate SARS-CoV-2 vaccine has a very high efficacy rate in an initial analysis of clinical trial data, according to the Financial Times.

Wired reports on a microbial analysis of sketches drawn by Leonardo DaVinci.

A new survey explores coronavirus vaccine hesitancy among Black and Latino individuals, the Washington Post reports.

In Nucleic Acids Research this week: the Aging Atlas database, a database of human metagenome-related metadata, and more.