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GenScript Single-Stranded DNA Service

GenScript has launched a new single-stranded DNA (ssDNA) service. The firm's service will provide researchers access to its ssDNA for CRISPR-based gene insertion, which it believes will speed up development of gene therapy, cell therapy, and transgenic animal moels for cancer research and treatment. GenScript said that it uses a enzymatic approach to develop high purity DNA oligos up to 3000 nucleotides long in larger quantities, with an undetectable level of DNA contamination and minimal DNA base damage. 

The Scan

Self-Reported Hearing Loss in Older Adults Begins Very Early in Life, Study Says

A JAMA Otolaryngology — Head & Neck Surgery study says polygenic risk scores associated with hearing loss in older adults is also associated with hearing decline in younger groups.

Genome-Wide Analysis Sheds Light on Genetics of ADHD

A genome-wide association study meta-analysis of attention-deficit hyperactivity disorder appearing in Nature Genetics links 76 genes to risk of having the disorder.

MicroRNA Cotargeting Linked to Lupus

A mouse-based study appearing in BMC Biology implicates two microRNAs with overlapping target sites in lupus.

Enzyme Involved in Lipid Metabolism Linked to Mutational Signatures

In Nature Genetics, a Wellcome Sanger Institute-led team found that APOBEC1 may contribute to the development of the SBS2 and SBS13 mutational signatures in the small intestine.