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GenScript Single-Stranded DNA Service

GenScript has launched a new single-stranded DNA (ssDNA) service. The firm's service will provide researchers access to its ssDNA for CRISPR-based gene insertion, which it believes will speed up development of gene therapy, cell therapy, and transgenic animal moels for cancer research and treatment. GenScript said that it uses a enzymatic approach to develop high purity DNA oligos up to 3000 nucleotides long in larger quantities, with an undetectable level of DNA contamination and minimal DNA base damage. 

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.