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GenScript Enhanced GenBrick Gene Synthesis Service

GenScript has launched an upgrade to its GenBrick Gene Synthesis platform, which gives researchers access to DNA sequences up to 200 kilobases long with 100 percent accuracy. GenScript said it has optimized the genome assembly process and enhanced its technology to better handle difficult sequences. It has also developed new technology to quickly and accurately create long DNA sequences in one step that are free of any mutations or negative clones. 

The GenBrick service has been tested and used in synthetic biology projects such as the Synthetic 2.0 Yeast Genome (Sc2.0) project, where it synthesized the long arm of yeast chromosome VI. 

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.