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Genome Diagnostics NGSengine

Genome Diagnostics has released a new version of its NGSengine human leukocyte antigen typing software. The updated NGSengine is now capable of exporting HLA typing results of individual samples directly to the Predicted Indirectly Recognizable HLA Epitopes (PIRCHE) matching-services website, thanks to a recent partnership between Netherlands-based GenDx and German firm PIRCHE. This, the company said, will give laboratories the ability to predict indirectly recognizable HLA epitopes for either hematopoietic stem cells or solid organs.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.