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GeneCast RUO Kits

South Korea-based liquid biopsy firm GeneCast has launched a set of research-use-only kits for BRAF, EGFR, and JAK2 mutation detection. The firm claims technical sensitivity for the BRAF assay as low as 0.0001 percent, and for the EGFR and JAK2 kits of 0.01 percent. The products use the company's ADPS quantitative PCR method, and the firm said it is working on gaining approval to offer the products for clinical use, filing a PMA submission with the US Food and Drug Administration, for the EGFR assay for example. GeneCast plans to launch additional RUO kits for KRAS, NRAS, PIK3CA, pTERT, IDH1, and IDH2 by the end of this year.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.