GenBank 206

Feb 17, 2015

GenBank 206 is now available via ftp from the National Center for Biotechnology Information.

Uncompressed flatfiles in this release require 700 gigabytes for sequence files only. The ASN.1 data require approximately 572 GB. Additional details are available here.

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Jul 13, 2018

Exosomics Siena SeleCTEV-DNA and SortEV-RNA

Exosomics Siena has launched its first proprietary liquid biopsy solutions, SeleCTEV-DNA and SortEV-RNA, which are both designed to aid selective isolation of tumor-derived nucleic acids from complex biofluids such as plasma or serum.

Unlike most liquid biopsy methods where total nucleic acids are harvested from blood Exosomics Siena's technology is based on the isolation and enrichment of tumor-derived exosomes. The new kits use unique affinity methods to select exosomes from which the DNA or RNA, respectively, can be extracted. Additionally, the SeleCTEV-DNA kit can be used to isolate circulating cell-free DNA in addition to DNA borne by exosomes.

Both tools are currently for research use only.

Jul 12, 2018

Medical and Biological Laboratories MEBRIGHT NUDT15 Kit

Medical and Biological Laboratories of Japan has launched the MEBRIGHT NUDT15 kit for detecting genetic polymorphisms in the NUDT15 (Nudix Hydrolase 15) gene, which can predict serious side effects of thiopurine drugs.

Thiopurine drugs are often prescribed to patients with inflammatory bowel disease, leukemia, rheumatic disease, or after an organ transplant, but clinical studies have shown that the drugs can induce adverse effects such as severe leukopenia and alopecia universalis within about eight weeks. A strong correlation has also been demonstrated between the development of serious adverse effects of thiopurine drugs and polymorphism in NUDT15, particularly among East Asians, Medical and Biological Laboratories said.

Using real-time PCR, the kit detects polymorphisms at codon 139 of NUDT15 in DNA from a patient's blood. The kit requires a processing time of two hours and simultaneously measures multiple samples, the firm said. The kit, which was jointly developed with Tohoku University, was approved as an in vitro diagnostic test by Japan's Pharmaceutical and Medical Device Agency in April.

Jul 11, 2018

Dante Labs Whole GenomeZ

Dante Labs has launched a whole-genome sequencing methodology called Whole GenomeZ. Whole GenomeZ provides 130X coverage to the entire exome and 30X coverage to the rest of the genome. The cost of the test is $999 or €849, which is below the standard cost of whole-genome sequencing at most facilities, the firm said. 

Jul 10, 2018

New England BioLabs NEBNext Direct Custom Ready Panels

New England Biolabs has launched the NEBNext Direct Custom Ready Panels, which allow users to design customized panels from a library of pre-synthesized baits for about 850 genes associated with a number of human diseases. The panels use the NEBNext Direct target enrichment technology, which hybridizes genomic DNA with biotinylated probes and converts the captured molecules into sequence-ready libraries. A unique molecular identifier tag is added to each DNA molecule prior to the final PCR amplification step. New England Biolabs said it will periodically update the panels to add new genes to the list and will update content corresponding to changes in gene definition and coordinates.

Jul 10, 2018

Ultivue UltiMapper Reagents

Ultivue has launched its UltiMapper portfolio of reagents for whole-slide protein biomarker spatial detection and analysis in tissue. More specifically, the company's UltiMapper I/O reagent kits are ready to use and enable profiling and characterization of tumor immuno-oncology markers in formalin-fixed, paraffin-embedded samples. Analysis can be conducted using instrumentation and software found in most immunohistochemistry laboratories, Ultivue said. The reagents are powered by Ultivue's InSituPlex technology, which combines DNA-barcoded antibodies with complementary fluorescent DNA barcodes.

Jul 06, 2018

Rheonix Literia PatternAlert Assay

Rheonix has launched its Listeria PatternAlert assay, a method to quickly identify molecular patterns from Listeria strains. The assay detects the presence or absence of independently occurring genetic targets that can sort Listeria strains into thousands of potential patterns. Each pattern generated by the assay covers a group of strains and can also include multiple species of Listeria. Running on the firm's Encompass Optimum platform, the assay provides results in six hours after a positive screen without requiring an isolate. The method will help food producers to identify and trace back sources of Listeria contamination, allowing users to minimize the risk of contamination and recall.

Jul 03, 2018

Devyser Thalassemia Kit

Devyser has released the Devyser Thalassemia kit for the analysis of sequence variants in the HBA1, HBA2, and HBB genes in human genomic DNA. Compatible with the Illumina MiSeq and MiniSeq instruments, the research-use-only kit detects all mutations in these genes including SNVs, indels, and copy number variations. The PCR chemistry provides complete and uniform coverage of targeted regions, and enables a high level of overlapping amplicon multiplexing and NGS library preparation with no sample splitting, the company said. 

Jul 02, 2018

WuXi NextCode LifeCode.ai

WuXi NextCode has launched LifeCode.ai, a health databank that uses blockchain technology to manage health data securely. The databank encrypts and stores user data multiple times, and the information can only be accessed with user-specific authorization, the firm said. In addition, each change in the data is recorded in a blockchain. WuXi has designed the databank for both individual and enterprise use.

Jun 28, 2018

Thermo Fisher Scientific Oncomine TCR Beta-SR Assay

Thermo Fisher Scientific has launched the Oncomine TCR Beta-SR Assay, a sequencing assay to characterize T-cell clonality in the tumor microenvironment. The test will interrogate the CDR3 region of the beta chain of the T-cell receptor, a region that is responsible for antigen recognition and helps to identify T-cell clones. The assay uses dual barcode indexing, which allows identification of low-frequency clones for potential tracking of minimal residual disease. It is optimized for formalin-fixed paraffin-embedded tissue, peripheral blood leukocytes, peripheral blood mononuclear cells, or cell-free DNA, and can work with either DNA or RNA as input.

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Thermo Fisher Scientific Invitrogen TaqMan & SYBR Green Fast Advanced Cells-to-CT Kits

Thermo Fisher Scientific has launched Invitrogen TaqMan & SYBR Green Fast Advanced Cells-to-CT kits for real-time RT-PCR. The kits allow for a faster reverse transcriptase reaction and use a qPCR master mix system that is optimized to improve sensitivity to detect rare transcripts. They are designed for high-throughput gene expression analysis directly from cultured cells without RNA purification. The kits contain updated reverse transcription reagents for cDNA synthesis and faster TaqMan or SYBR Green master mixes for real-time PCR analysis.

Jun 25, 2018

Invitae Carrier Screen

Invitae has launched several genetic carrier screening products. The Invitae Comprehensive Carrier Screen uses next-generation sequencing to analyze 287 genes linked to serious genetic disorders and identifies more than 99 percent of disease-causing changes in most of the genes analyzed. In addition, the company offers a 46-gene test, called Invitae Broad Pan-Ethnic Carrier Screen, that assesses a smaller set of common disorders, and a test called Invitae Pan-Ethnic Carrier Screen that analyzes three genes associated with cystic fibrosis, spinal muscular atrophy, and fragile X syndrome. Both of the smaller panels can be supplemented with a customized set of genes from the large panel and with 13 genes not included in any pre-curated panel. The Invitae Carrier Screen replaces the GeneVu carrier screen from Good Start Genetics, which Invitae acquired last year.

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10x Genomics Single Cell Mouse Immune Profiling Solution

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The Associated Press reports that the US government wasted $341,000 on travel by former Health and Human Services Secretary Tom Price.

Women who post YouTube science videos get more critical comments and more comments about their appearance than male video hosts, the New York Times reports.

The Wall Street Journal writes that participating in genetic research brings up the specter of past research ethics lapses for some African Americans.

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