Genalice Map's Population Calling Module

Sep 24, 2015

Genalice has added a new module to its Genalice Map NGS data analysis suite. The so-called population calling module enables users to explore variants accross multiple samples as part of cohort studies. 

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Oct 18, 2017

Illumina NovaSeq S4 Flow Cell, Xp Workflow

Illumina has launched its S4 flow cell and reagent kit for its NovaSeq 6000 next-generation sequencing instrument and plans to launch its NovaSeq Xp workflow before the end of the year.

The S4 flow cell can deliver up to 6 terabases of data, equivalent to up to 48 human genomes or 384 exomes, in two days. The Xp workflow includes the Xp flow cell loading dock and reagents and enables users to load libraries directly onto individual flow cell lanes, which enables users to mix library types or different approaches for sample indexing. 

Oct 17, 2017

Phosphorus Elements Genetic Testing Software

Computational genomics company Phosphorus has introduced Elements, a software platform with six different modules for managing various processes of diagnostic genetic testing. The software-as-a-service platform is aimed at laboratories, community hospitals, and health centers looking to start up genomics and precision medicine programs.

Oct 17, 2017

Desktop Genetics DESKGEN Series CRISPR Libraries

Desktop Genetics launched its DESKGEN Series CRISPR Libraries to support gene editing efforts in academic and biopharma settings. The series consists of six new CRISPR library products, each of which can be tailored to an investigator's list of genomic targets using any delivery method. Each product addresses a particular experimental application of the genome editing technology, the company said. Disrupt Libraries can be used to functionally knock out genes to reveal novel druggable targets and essential pathways; Tile Libraries saturate coding and non-coding regions to reveal genotype-phenotype relationships; SNP-In Libraries allow high-throughput insertion and deletion knockins across the genome; Interfere Libraries silence target gene expression with CRISPRi; Activate Libraries allow over-expression of target genes with CRISPRa; and Predict Libraries provide a unique scoring algorithm optimized for teams working on specific model cell lines or organisms, enabling other libraries to be designed more effectively.

Once the company receives a customer's list of targets, it designs the library using its proprietary DESKGEN AI and suite of bioinformatics pipelines. Once the designs are complete, the company manufactures the library in a variety of ready-to-use formats including plasmids, RNA, ribonucleoproteins, or as lentivirus, in either pooled or arrayed format.

Oct 16, 2017

Genomenon Mastermind Search Engine

Genomenon has announced the limited availability of a free version of its Mastermind genomic search engine for clinical, research, and academic institutions. The free offering lacks some of the features of Mastermind Professional Edition, including genomic data analysis services and workflow automation tools, but it has the same targeted search of genomic research that filters out results not clinically relevant to those interested in genetic relationships to specific diseases. For now, Mastermind Free Edition is available by invitation only. 

Oct 13, 2017

Swift Biosciences Accel-Amplicon Custom NGS Panels

Swift Biosciences has launched Accel-Amplicon Custom NGS Panels, a targeted DNA sequencing product that enables clinical researchers to rapidly design highly focused panels to discover, validate, and screen disease genes and their variants. The platform-agnostic panel supports a wide range of input sample types including fresh and fresh-frozen tissue, whole blood, blood spot cards, formalin-fixed paraffin-embedded tissue, cell-free DNA, circulating tumor DNA, buccal swabs, whole genome amplified DNA and purified DNA. The panels require 10 nanograms of sample input, and enables library prep in under two hours. Swift said that it also partnered with informatics firm Genialis to integrate alignment, trimming, QC, and variant calling into one simple pipeline.

Oct 12, 2017

GenePOC Group B Streptococcus Direct Swab

GenePOC launched its Group B Streptococcus Direct Swab molecular test in Europe. The assay is for use on Revogene, the firm's microfluidic real-time PCR instrument, and will help minimize the risk of GBS transmission from mother to baby. It also will help to optimize antibiotic stewardship, said GenePOC, a member of the Debiopharm Group. 

Oct 11, 2017

iGenomX Riptide High-Throughput Rapid Library Prep Kit

iGenomX has launched Riptide High-Throughput Rapid Library Prep (HT-RLP), which allows users to create up to 960 next-generation sequencing libraries in a short time and at low cost. According to the company, the protocol is simple, easy to automate, and avoids cumbersome processing steps such as fragmentation, repair, and DNA ligation. The kit is intended for use with small genomes and synthetic DNA constructs for applications such as microbiome screening, whole-genome sequencing of microbial genomes, quality control of synthetic DNA products, and high-throughput genotyping by sequencing.

Oct 09, 2017

Fast Track Diagnostics Enteric Fever Kit

Fast Track Diagnostics has launched a kit to detect the pathogens that cause enteric fever, also known as typhoid or paratyphoid fever. The FTlyo Enteric fever kit includes blood collection tubes containing a proprietary Salmonella enrichment broth, ready-to-use multiplex PCR for detection of Salmonella enterica serovar Typhi and Salmonella enterica serovar Paratyphi, and an internal control. The reagents required for the PCR are lyophilized in single-patient sample tubes that can be stored at room temperature, and clinicians need only add extracted nucleic acids to begin the eight-hour detection workflow.

Oct 06, 2017

Xifin LIS Anywhere NGS Module

Xifin has added a next-generation sequencing model to its LIS Anywhere laboratory information system to support precision medicine. The new module, which will be on display at the College of American Pathologists annual meeting, is intended to help labs build their molecular diagnostics capabilities and improve genomics workflow.

Oct 05, 2017

Illumina Nextera DNA Flex

Illumina has launched its Nextera DNA Flex, a whole-genome sequencing library preparation product that eliminates the need for sample prep of whole blood and saliva, and cuts down on steps in the library prep workflow. The new product utilizes On-Bead Tagmentation, which reduces total library prep turnaround time to less than three hours, the firm said. Among the applications for Nextera DNA Flex are sequencing of human or other large or complex genomes, amplicons, and microbial, parasitic, and fungal species, Illumina added.

Oct 05, 2017

DNAnexus CloudSeq

DNAnexus this week launched its DNAnexus CloudSeq solution, a suite of cloud-based tools and professional services specifically designed to support the informatics infrastructure needs of customers using Illumina's NovaSeq sequencing systems. The CloudSeq solution includes full access to the DNAnexus Platform, a fixed pricing model, and on-demand cloud-enablement and bioinformatics support to help laboratories securely scale operations in as little as four weeks, the firm said.

Oct 05, 2017

ResearchDx, Menarini Silicon Biosystems DEPArray HER2

ResearchDx and Menarini Silicon Biosystems jointly launched DEPArray HER2, a FISH-based laboratory-developed test performed by PacificDx, a wholly owned subsidiary of ResearchDx. The test leverages cell isolation capabilities of DEPArray NxT technology, enabling pure tumor cell populations to be isolated from heterogeneous tumor/normal tissue samples.

Oct 04, 2017

DiaSorin group C and group G Streptococcus Primer Pairs

DiaSorin Molecular launched the primer pairs, group C and group G Streptococcus for use in laboratory-developed molecular tests. Classified as analyte-specific reagents, they can be used by high-complexity labs to develop their own LDTs. 

Oct 03, 2017

Cellecta Human and Mouse Genome-Wide CRISPRa and CRISPRi Libraries and Mouse CRISPR Knockout Library

Cellecta added CRISPRa and CRISPRi genome-wide, human and mouse pooled screening libraries to its portfolio of CRISPR products and services. Cellecta also supplemented its current portfolio of CRISPR gene knockout libraries by adding a Mouse Genome-Wide CRISPR Knockout Library. These new additions to Cellecta's CRISPR portfolio enable researchers to study enhanced gene activation or gene inhibition without modifying genomic DNA, the company said. The gene-regulating CRISPRa and CRISPRi variations make use of an altered CRISPR protein to enhance or inhibit gene expression, rather than inducing mutational changes in a gene's coding sequence. Access to these new libraries provide researchers with new tools to identify potential drug targets or biomarkers, and elucidate mechanisms of drug action.

Key features of the new Cellecta CRISPRa and CRISPRi libraries include single-module format, with each library expressing some 106,000 sgRNAs (human) and 109,000 sgRNAs (mouse) averaging five sgRNAs per gene promoter region; CRISPRa and CRISPRi libraries targeting approximately 19,000 human genes and almost 20,000 mouse genes; and approximately 4,000 non-targeting sgRNA controls.

The new CRISPR Mouse Genome-Wide Knockout Library, based on the canonical CRISPR/Cas9 system, extends knockout screening capability to mouse model systems. The Cellecta CRISPR mouse knockout library targets all mouse protein-coding genes and features approximately 80,000 constructs comprise the single-module library, four sgRNAs target functional domains and conserved transcript regions in each of 19,600 mouse genes, and complete panel of controls include standard, non-targeting controls.

Oct 03, 2017

CogenDx DxWound

CogenDx has launched its newest test offering, DxWound. The test uses DNA-based technology to provide sensitive detection of an array of microbes, including aerobic and anaerobic bacteria, fungi, and antibiotic resistance genes. Test results equip clinicians to rapidly and accuratley identify pathogens causing infections and choose antibiotics with improved likelihood for success. DxWound utilizes a swab to collect microbial DNA directly from the infection site and leverages a transport buffer that preserves the wound microbiome during specimen transit. Test results are delivered the next business day from specimen receipt at the laboratory. 

New Mexico is re-doing its proposed science education standards after criticism, the Associated Press reports.

Agbio executives say gene editing will speed up breeding efforts, according to the Wall Street Journal.

La Trobe University's Jenny Graves has won the $250,000 Prime Minister's Prize for Science, the Guardian reports.

In Cell this week: post-treatment changes to melanoma genome, multi-omics analysis of muscle-invasive bladder cancer, and more.