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Genalice Map 2.4.0

Genalice has released Genalice 2.4.0, the latest iteration of of its software for secondary analysis of next-generation sequencing data. This release includes a new somatic calling module that helps users distinguish between variants found in normal and tumor tissue samples. According to the company, the new module outperforms existing tools such as MuTecT, FreeBayes, and VarScan in terms of both speed and accuracy. Other updates to the software include a tool that lets users create profiles for defined cohorts for targeted cell amplification and suppression as well as a tool for detecting copy number variants.

The Scan

Study Links Genetic Risk for ADHD With Alzheimer's Disease

A higher polygenic risk score for attention-deficit/hyperactivity disorder is also linked to cognitive decline and Alzheimer's disease, a new study in Molecular Psychiatry finds.

Study Offers Insights Into Role of Structural Variants in Cancer

A new study in Nature using cell lines shows that structural variants can enable oncogene activation.

Computer Model Uses Genetics, Health Data to Predict Mental Disorders

A new model in JAMA Psychiatry finds combining genetic and health record data can predict a mental disorder diagnosis before one is made clinically.

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.