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Genalice Map 2.4.0

Genalice has released Genalice 2.4.0, the latest iteration of of its software for secondary analysis of next-generation sequencing data. This release includes a new somatic calling module that helps users distinguish between variants found in normal and tumor tissue samples. According to the company, the new module outperforms existing tools such as MuTecT, FreeBayes, and VarScan in terms of both speed and accuracy. Other updates to the software include a tool that lets users create profiles for defined cohorts for targeted cell amplification and suppression as well as a tool for detecting copy number variants.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.