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Fluxion Biosciences Spotlight 59

Fluxion Biosciences has launched its Spotlight 59 Oncology Panel, a next-generation sequencing-based assay designed for liquid biopsy analyses. Used in conjunction with Fluxion's IsoFlux Liquid Biopsy System, the new panel is a complete sample-to-answer assay for high sensitivity mutation detection of solid tumor cancers from blood samples, the company said. In allowing ultra-sensitive variant detection from low input quantities of DNA, the panel is also potentially useful not only for liquid biopsy samples like circulating tumor cells or cell-free DNA, but also other challenging sample types such as FFPE.

For liquid biopsies, the panel's high sensitivity, driven by a bioinformatics method called ERASE-Seq, allows sensitivity to 0.1 percent allele frequency with no false positives, Fluxion said. The panel uses a 277-amplicon design based on Swift Biosciences Accel-Amplicon chemistry, covers hotspots in 59 clinically-relevant oncology-related genes, and generates multiplex libraries compatible with Illumina sequencing platforms, without the need for complicated molecular barcodes. 

The Scan

And Back

The New York Times reports that missing SARS-CoV-2 genome sequences are back in a different database.

Lacks Family Hires Attorney

A lawyer for the family of Henrietta Lacks plans to seek compensation from pharmaceutical companies that have used her cancer cells in product development, the Baltimore Sun reports.

For the Unknown

The Associated Press reports that family members are calling on the US military to use new DNA analysis techniques to identify unknown sailors and Marines who were on the USS Arizona.

PLOS Papers on Congenital Heart Disease, COVID-19 Infection Host MicroRNAs, Multiple Malformation Mutations

In PLOS this week: new genes linked to congenital heart disease, microRNAs with altered expression in COVID-19, and more.