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Fluidigm Single-Cell ATAC-seq for C1 System

Fluidigm has introduced Single-Cell ATAC-seq, an epigenetics application for the C1 single-cell genomics platform. The new application allows researchers to explore the regulatory systems that drive cellular function, and is freely available on Script Hub, a new web portal within Fluidigm's C1 Open App program. In a study published this week in Nature, researchers from Stanford University and Fluidigm used ATAC-seq to identify single-cell DNA accessibility profiles from diverse cell types. Understanding the accessible regions of the genome will reveal the role of DNA-binding proteins, nucleosomes, and chromatin compaction in regulating gene expression, Fluidigm noted. Before the C1 and ATAC-seq, researchers needed at least 500 cells to identify accessible chromatin regions, which misrepresented the heterogeneity present in the biological system, the company noted.

The Scan

Shape of Them All

According to BBC News, researchers have developed a protein structure database that includes much of the human proteome.

For Flu and More

The Wall Street Journal reports that several vaccine developers are working on mRNA-based vaccines for influenza.

To Boost Women

China's Ministry of Science and Technology aims to boost the number of female researchers through a new policy, reports the South China Morning Post.

Science Papers Describe Approach to Predict Chemotherapeutic Response, Role of Transcriptional Noise

In Science this week: neural network to predict chemotherapeutic response in cancer patients, and more.