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Fluidigm REAP-Seq Protocol for C1 System

Fluidigm has introduced a REAP-seq (RNA expression and protein sequencing) protocol for use with its C1 sample prep system for single-cell genomics. C1 REAP-seq enables characterization of unique cellular subtypes and functional states by measuring the expression of both cellular proteins and RNAs. Users can pair the protocol with functional imaging assays that measure differences in cell size, morphology, or phenotype within the clear C1 microfluidic cell chambers. The firm developed C1 REAP-seq in collaboration with Merck for co-detection of both cellular protein and RNA using microfluidic technology.

The Scan

Germline-Targeting HIV Vaccine Shows Promise in Phase I Trial

A National Institutes of Health-led team reports in Science that a broadly neutralizing antibody HIV vaccine induced bnAb precursors in 97 percent of those given the vaccine.

Study Uncovers Genetic Mutation in Childhood Glaucoma

A study in the Journal of Clinical Investigation ties a heterozygous missense variant in thrombospondin 1 to childhood glaucoma.

Gene Co-Expression Database for Humans, Model Organisms Gets Update

GeneFriends has been updated to include gene and transcript co-expression networks based on RNA-seq data from 46,475 human and 34,322 mouse samples, a new paper in Nucleic Acids Research says.

New Study Investigates Genomics of Fanconi Anemia Repair Pathway in Cancer

A Rockefeller University team reports in Nature that FA repair deficiency leads to structural variants that can contribute to genomic instability.