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Fluidigm Medium-Cell HT IFC

Fluidigm has launched its medium cell, high-throughput integrated fluidic circuit to isolate single cells for mRNA sequencing analysis. The circuit captures up to 800 medium-size cells with higher single-cell capture efficiency, which enables researchers to scale cell lineage studies using Fluidigm's C1 system, the company said. The new workflow supports the identification of cell subpopulations present at low abundance across a wide range of cell types, including cancer and stem cells.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.