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Fluidigm Callisto Cell-Culture System

Fluidigm has launched the Callisto system, a fully automated and programmable microfluidic cell culture system that integrates multifactorial dosing in 32 individual chambers for simultaneous cell culture. The system consists of an automated instrument, specialized integrated fluidic circuit, reagent kit, and software suite. With minimal intervention, the platform enables scientists to easily and precisely manipulate the biological pathways that regulate cellular activity and fate decisions while monitoring their viability and phenotypic effects over the course of each study, Fluidigm said. By running automated scripts in a nanoliter-scale reaction size, each experiment can be executed with higher efficiency and drastically reduced labor and heterogeneity compared to manual, plate-based studies, the company added.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.