Eurofins Genoma GeneSafe

Sep 07, 2017

Eurofins Genoma has introduced GeneSafe, a non-invasive prenatal test that screens for both de novo and inherited single-gene disorders. Current commercial NIPTs only screen for aneuploidies and microdeletions, the firm said. GeneSafe identifies fetal conditions that could be missed by traditional prenatal testing, detecting more than 40 severe genetic disorders that may occur in the absence of a family history of the condition. The company said it also detects disorders with an increased prevalence associated with advanced paternal age. The test requires a small blood sample and has a turnaround time of 10 days. It works as a complementary screen to traditional NIPT, providing a more complete picture of the risk of a pregnancy being affected by a genetic disorder, the company noted.

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Nov 17, 2017

Covaris 96 OneTUBE-10 Adaptive Focused Acoustics Plate

Covaris has released the 96 OneTUBE-10 AFA Plate, which uses the company's Adaptive Focused Acoustics technology to eliminate mechanical DNA shearing in the next-generation sequencing library prep workflow through end repair, A-tailing, ligation, and SPRI cleanup. OneTUBE-10 is specifically designed for use with Covaris' AFA technology for DNA shearing at volumes of 10 to 50 µL; is compatible with standard heat blocks, magnets, and thermocyclers; and can be used on any liquid-handling platform, the company said.

Nov 17, 2017

Canon BioMedical Novallele Copy Number Assays for SMA Research

Canon BioMedical has launched Novallele copy number assays for spinal muscular atrophy research. The PCR-based method only requires a thermocycler capable of high-resolution melting (HRM) and a single sample replicate. The assays are optimized to work with multiple HRM-capable thermocyclers and numerous DNA extraction methods. With some thermocyclers, results can be generated in under an hour, Canon said.

Nov 16, 2017

Edico Dragen Clinical Genomics Information System

Edico Genome has introduced the Dragen Clinical Genomics Information System, software designed to help clinical laboratories develop sequencing-based tests. Dragen CGIS is meant to integrate Edico's various somatic, germline, joint genotyping, and RNA gene fusion pipelines with various other systems Edico has partnered with, including Fabric Genomics' Opal Clinical genome interpretation software.

Nov 16, 2017

True Health Respiratory Pathogen Screening

True Health launched the respiratory pathogen screening, a single test that targets 21 viral and bacterial pathogens to help clinicians determine the correct treatment for respiratory illnesses during cold and flu season. True Health's program is built to identify the specific cause of the infection so clinicians can prescribe an effective treatment. The 21-pathogen screen has a one day turn around from receipt of the specimen at the lab to delivering the results. The screen is conducted using multiplex PCR.

Nov 15, 2017

Circulogene Microsatellite Instability Biomarker Testing

Circulogene announced the availability of microsatellite instability biomarker testing for multiple cancer types. The test is immediately available to oncologists and pathologists, enabling them to identify patients eligible for treatment with Keytruda (pembrolizumab) across multiple cancer types, or Opdivo (nivolumab) for colorectal cancer. With the new assay, Circulogene now provides circulating DNA, RNA, and MSI cancer immunotherapy testing from a single tube of blood with a three-day turnaround time out of it CLIA-certified laboratory.

Nov 15, 2017

Promega Maxwell Modular Automated Nucleic Acid Prep System

Promega has launched a modular automated liquid-handling and purification system for its Maxwell nucleic acid preparation platform. The configurable system works with existing Promega Maxwell RSC instruments with a software upgrade. The Promega Portal Software allows the new and existing Maxwell RSC and Maxprep instruments to work together to transfer sample tracking information. Data can also be imported into a laboratory information management system. The Maxwell RSC 48 and Maxprep Liquid Handler are supplied with preprogrammed methods that allow the system to be used by anyone in the lab regardless of prior instrumentation experience, Promega said.

Nov 14, 2017

InSource Diagnostic ToxLok

InSource Diagnostic launched ToxLok for the verification of urine-based drug tests. ToxLok uses a buccal swab along with the urine sample, and DNA markers from the swab and urine are matched. The test can identify synthetic urine and samples that may be from a friend or relative. ToxLok uses 52 genetic markers to identify each patient and urine sample. Analysis is done by qPCR and MALDI-TOF mass spectrometry. 

Nov 14, 2017

IQuity IsolateIBS-IBD

IQuity launched its IsolateIBS-IBD blood-based test for the identification of irritable bowel syndrom or inflammatory bowel disease. The Nashville, Tennessee-based company said the test can determine IBS and IBD earlier than is possible with other tests and has accuracy greater than 90 percent. It can determine whether a person's RNA profile indicates the presence of IBS or IBD, and within IBD it provides information to differentiate between Crohn's disease and ulcerative colitis. 

Nov 14, 2017

Horizon Discovery Edit-R CRISPRa Reagent Platform for Genome-Wide CRISPR Activation

Horizon Discovery has launched its reagent platform for CRISPR activation as the latest addition to the company's Edit-R portfolio for CRISPR-Cas9 genome engineering. The new Edit-R CRISPRa offering provides researchers interested in gain-of-function studies with a two-component system for drug discovery, disease modeling, or pathway analysis. The system is available in lentiviral and synthetic formats and is well-suited for robust overexpression in virtually any cell system, Horizon said. This format is also suitable for arrayed studies for high-throughput, complex phenotypic analysis.

The Edit-R CRISPRa portfolio includes genome-wide, pre-designed guide RNAs for human and mouse, as either a lentiviral expression plasmid, lentiviral particles, or a two-part synthetic guide RNA. The system further utilizes nuclease-deactivated Cas9 fused to three activation domains provided as lentiviral particles or purified plasmids.

Nov 13, 2017

Canopy Biosciences CRISPR Complete Gene Editing Kits

Canopy Biosciences has launched its CRISPR Complete Gene Editing Kits, which include everything a researcher needs to perform a gene editing experiment with the CRISPR-Cas9 system. Pricing for the kits start at $990 for a gene knockout kit. Kits are available for knockouts, knock-ins, point mutations, and many other project types, and include both design and synthesis of crRNAs, tracrRNA, Cas9 protein, genotyping primers, and donor (for knock-ins and point mutations).

Nov 10, 2017

TwistDx TwistAmp Liquid Kits

TwistDx recently launched TwistAmp Liquid kits, a range of liquid format recombinase polymerase amplification kits ideal for rapid testing applications and high-throughput laboratory use. RPA is an isothermal DNA/RNA amplification technology that the company says offers the same specificity as PCR but with much faster results – typically within three to 10 minutes.

The new kits are designed to simplify integration of RPA technology into existing laboratory workflows. The liquid format also simplifies the development of miniaturized or custom assay configurations and the creation of bulk master mixes, TwistDx said.

Nov 09, 2017

BioDiscovery NxClinical 4.0

BioDiscovery recently launched NxClinical 4.0, software for the interrogation of copy number, sequence variants, and allelic changes obtained from a single next-generation sequencing assay. The software incorporates all these genomic variations into a single database where a compound heterozygous event can easily be detected with interactive browser view and advanced filtering schemas that quickly narrow down the list of potential causal variants, the company said.

Nov 09, 2017

MedReleaf ReleafDx

Canadian medical cannabis firm MedReleaf is launching in that country ReleafDx, a genetic test to help physicians in the prescription of cannabis. Based on a cheek swab, the test analyzes a patient's DNA and health conditions, providing information that a doctor can use to determine what cannabis product will work best for an individual, and the proper dosage. Dynacare, a Laboratory Corporation of America company, will manage the sample analysis and results reporting. The cheek swab can be done in doctors' offices or at a Dynacare Laboratory and Health Services Centre. The samples are then sent to Dynacare for analysis. Results are returned to the doctor with recommendations on the proper dosage of medReleaf's products. The test will be available in Canada starting in January.

Nov 08, 2017

3dbiosurfaces, Stratec Consumables 3D NS-NC slide

3dbiosurfaces and Stratec Consumables have launched the 3D NS-NC slide, a microarray substrate based on 3dbiosurfaces' technology. Stratec Consumables is a wholly owned subsidiary of Stratec. The slide offers increased signal intensity, more uniform spots, and other benefits over other microarray substrates, the firms said in a statement, adding it is especially attractive for protein applications as the surfaces allow proteins to maintain their shape and function.

Nov 08, 2017

New England Biolabs NEBNext Ultra II FS DNA Library Prep Kit

New England Biolabs has launched the NEBNext Ultra II FS Library Prep Kit for enzyme-based DNA fragmentation and library preparation for next-generation sequencing. The kit combines fragmentation, end repair, and dA-tailing in a single tube. Input DNA amounts can range from 100 picograms to 0.5 micrograms and library preparation can be completed in 2.5 hours, with less than 15 minutes of hands-on time. The kit is also available with SPRISelect beads for size selection and cleanup steps.

Researchers test gene therapy targeting a different cancer protein in a new trial, the New York Times reports.

Pennsylvania State University researchers found that salivary microRNAs could predict which kids would have longer concussion symptoms, according to NPR.

The Associated Press reports Alex Azar, the new Department of Health and Human Services secretary nominee, made millions of dollars as a pharmaceutical executive.

In PNAS this week: immune profiling of breast cancer, transposable element patterns in rice, and more.

Dec
05
Sponsored by
Agilent

This webinar will discuss a molecular barcode-based error correction method that enables combined mutation detection and DNA copy number profiling through circulating tumor DNA sequencing.