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EntroGen Multiplexed Leukemia Translocation Panel

EntroGen has launched the Leukemia Translocation panel. It is a multiplexed, one-step real-time PCR assay that detects eleven variants in 6 common leukemia associated translocations simultaneously. The panel detects and identifies AML1-ETO, CBFB-MYH11, MLL-AF4, TEL-AML1, E2A-PBX1, and PML-RARA fusion gene transcripts from total RNA isolated from blood or bone marrow. The product is compatible with several leading multi-channel real-time PCR instruments capable of detecting four commonly used fluorescent probes and produces results in just 90 minutes, the company said. It can also be run together with the company's p190 and p120 real-time PCR kits for a comprehensive test for fusion genes implicated in CML, ALL, APL, and AML, the company said.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.