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Swift Biosciences is now offering early access to its Swift 2S Turbo Library Kit. The kit enables researchers to complete library prep workflow in two hours with as low as one nanogram of input. Researchers can use a range of sample types, including fresh and fresh-frozen tissue, human or microbial genomic DNA, formalin-fixed paraffin-embedded samples, and PCR amplicons.

AMS Biotechnology has released CRISPR-Cas9 editing kits for gene knockout, gene knock-in, and gene mutation applications. Developed by the firm's genetic engineers, the AMSBIO CRISPR Complete kits are made for specific projects including knockouts, knock-ins, point mutations, gene replacements, humanizations, tagging, and more. 

Custom-designed CRISPR Complete kits include tracrRNA and Cas9 nuclease, as well as crRNA and donor constructs that are also custom-designed for the project. The firm can offer the donor construct as an oligonucleotide or plasmid, depending on the project's needs.

Exosomics Siena has launched its first proprietary liquid biopsy solutions, SeleCTEV-DNA and SortEV-RNA, which are both designed to aid selective isolation of tumor-derived nucleic acids from complex biofluids such as plasma or serum.

Unlike most liquid biopsy methods where total nucleic acids are harvested from blood Exosomics Siena's technology is based on the isolation and enrichment of tumor-derived exosomes. The new kits use unique affinity methods to select exosomes from which the DNA or RNA, respectively, can be extracted. Additionally, the SeleCTEV-DNA kit can be used to isolate circulating cell-free DNA in addition to DNA borne by exosomes.

Both tools are currently for research use only.

Dante Labs has launched a whole-genome sequencing methodology called Whole GenomeZ. Whole GenomeZ provides 130X coverage to the entire exome and 30X coverage to the rest of the genome. The cost of the test is $999 or €849, which is below the standard cost of whole-genome sequencing at most facilities, the firm said. 

Ultivue has launched its UltiMapper portfolio of reagents for whole-slide protein biomarker spatial detection and analysis in tissue. More specifically, the company's UltiMapper I/O reagent kits are ready to use and enable profiling and characterization of tumor immuno-oncology markers in formalin-fixed, paraffin-embedded samples. Analysis can be conducted using instrumentation and software found in most immunohistochemistry laboratories, Ultivue said. The reagents are powered by Ultivue's InSituPlex technology, which combines DNA-barcoded antibodies with complementary fluorescent DNA barcodes.

Devyser has released the Devyser Thalassemia kit for the analysis of sequence variants in the HBA1, HBA2, and HBB genes in human genomic DNA. Compatible with the Illumina MiSeq and MiniSeq instruments, the research-use-only kit detects all mutations in these genes including SNVs, indels, and copy number variations. The PCR chemistry provides complete and uniform coverage of targeted regions, and enables a high level of overlapping amplicon multiplexing and NGS library preparation with no sample splitting, the company said. 

Thermo Fisher Scientific has launched the Oncomine TCR Beta-SR Assay, a sequencing assay to characterize T-cell clonality in the tumor microenvironment. The test will interrogate the CDR3 region of the beta chain of the T-cell receptor, a region that is responsible for antigen recognition and helps to identify T-cell clones. The assay uses dual barcode indexing, which allows identification of low-frequency clones for potential tracking of minimal residual disease. It is optimized for formalin-fixed paraffin-embedded tissue, peripheral blood leukocytes, peripheral blood mononuclear cells, or cell-free DNA, and can work with either DNA or RNA as input.