DNAnexus CloudSeq

Oct 05, 2017

DNAnexus this week launched its DNAnexus CloudSeq solution, a suite of cloud-based tools and professional services specifically designed to support the informatics infrastructure needs of customers using Illumina's NovaSeq sequencing systems. The CloudSeq solution includes full access to the DNAnexus Platform, a fixed pricing model, and on-demand cloud-enablement and bioinformatics support to help laboratories securely scale operations in as little as four weeks, the firm said.

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Sep 21, 2018

Paragon Genomics ParagonDesigner

Paragon Genomics has launched ParagonDesigner, a web-based tool that enables rapid design of CleanPlex Custom NGS Panels. The online portal features a streamlined, user-friendly interface that simplifies the assay design process, allowing researchers to build customized next-generation sequencing assays for their specific needs. The custom panels are powered by Paragon's CleanPlex technology, an ultra-high multiplexed PCR-based target enrichment chemistry that makes it possible to include a large number of genomic targets in a single assay. 
 
With ParagonDesigner, users define the content of their custom NGS assays by submitting their targets online. ParagonDesigner features a database of more than 1,300 pre-designed, clinically-relevant human genes, allowing CleanPlex Custom NGS Panels to be instantly assembled for most applications. The design tool also issues a report on the estimated panel size and design coverage for review prior to submission. Custom NGS panels are delivered in two to four weeks, the company said.
Sep 20, 2018

Precipio EGFR Liquid Biopsy Kit

Precipio has launched a new liquid biopsy ICEme kit, which uses the company's ICE-COLD PCR technology to enrich and detect cancer mutations in EGFR exons 18, 19, 20, and 21. The kit uses either qPCR or Sanger platforms with sensitivity down to 0.1 percent allele frequency. The new product complements Precipio's previously-launched TKI-resistance detection kit, which includes assays for EGFR exon 20 T790M and C797S resistance mutations.

Sep 19, 2018

Genomenon Mastermind Genomic Search Engine

The latest release of Genomenon's Mastermind Genomic Search Engine indexes approximately 500,000 new genomic variants from supplemental data found in scientific publications. Most precision medicine tools have not been able to provide insight into supplemental data without manual curation due to the lack of a common file format, the company noted. Supplemental data is often published as an Excel, PDF, .csv, Word, text, or image file. Genomenon said that it overcame this challenge by engineering its indexing pipeline to ingest these different file formats and applying its proprietary Genomic Language Processing technology to index the content for easy retrieval by researchers. 

Sep 19, 2018

Circulogene BRCA1/2 Testing

Circulogene has included somatic BRCA1 and BRCA2 blood testing to its testing menu. The addition of somatic BRCA1/2 testing allows the company to perform paired somatic and germline testing, the Birmingham, Alabama-based molecular diagnostics firm said. The paired testing is a single blood-tube test that can detect acquired mutations and inherited variants in patients with advanced breast, ovarian, and other cancers.

Sep 18, 2018

Roche Navify Clinical Trial Match, Navify Publication Search

Roche has launched two Navify clinical decision support apps, Navify Clinical Trial Match and Navify Publication Search, to help oncologists access clinical trial information and publications. Both are available on the Navify Tumor Board platform.

The Navify Clinical Trial Match app identifies clinical trial options from 11 international registries, based on patient-specific attributes such as age, sex, biomarkers, and various tumor attributes. The registries include ClinicalTrials.gov, the German Clinical Trials Registry, and the European Clinical Trials Registry. The Navify Publication Search app mines several publication sources, including PubMed, the American Society of Clinical Oncology, and the American Association of Central Cancer Registries, for relevant literature. The content of both apps is provided by MolecularMatch, a clinical informatics company.

Roche said it plans to add more apps, including from partners and third parties, in the future.

Sep 18, 2018

Amsbio circulating tumor DNA reference standards

Amsbio has launched a new range of circulating tumor DNA reference standards: a set of highly characterized, quantitative multiplex quality controls to support the development of new assays. The standards are engineered to mimic the fragmentation profile of nucleosomal ctDNA (aproximately 166 bp) observed in real patient samples across a range of allele frequencies. Pre-validated by digital PCR, the kits include cancer-associated mutations in EGFR, PIK3CA, NRAS and KRAS, and are available as purified DNA or in a synthetica plasma.
 

Sep 13, 2018

Viracor Eurofins CMV Resistance:Letermovir

Viracor Eurofins has launched CMV Resistance:Letermovir, a cytomegalovirus gene sequencing assay for the detection of resistance to Prevymis (letermovir), an antiviral for use in adult hematopoietic stem cell transplant patients. The assay is available as a standalone test or as a complete panel with the other CMV drugs as CMV Resistance: Letermovir, Ganciclovir, Foscarnet, Cidofovir. Viracor Eurofins said that resistance to Prevymis has not been detected in treatment-naive patients, but noted that clinical trials have shown that resistance can develop in the UL56 gene after exposure for some HSCT patients. 

Sep 13, 2018

ABclonal Technology DNA, RNA Library Prep

ABclonal Technology has launched next-generation sequencing library prep kits for DNA and RNA sequencing, including its Rapid DNA Lib Prep Kit, StepWise DNA kit, and both stranded and non-stranded mRNA library prep kits. The kits are compatible with Illumina sequencing technology and have a 70 percent DNA conversion efficiency with 500 picograms of input, the company said. They range in price from $218 to $558.

Sep 12, 2018

Fluidic Analytics Fluidity One

Fluidic Analytics has announced the launch of its Fluidity One system, which offers researchers the ability to observe protein behavior by measuring the size and concentrations in their native state without the need for surfaces or matrices. Based on the firm's fluidic separation and detection technology, the system analyses protein in solution and in their natural state using microfluidic diffusional sizing. The tool uses as little as 50 nanograms and produces results in less than 10 minutes. 

Sep 11, 2018

Empirical Bioscience EB Pure Plasmid Mini-Prep Kit

Empirical Bioscience has launched its new EB Pure Plasmid Mini-Prep Kit, which combines the firm's High-Bind technology with alkaline-SDS lysis of bacterial cells. The kit's High-Bind technology reversibly binds DNA or RNA under optimized conditions, removing proteins and other contaminants. It requires one to five milliliters of bacterial culture and delivers results in less than 30 minutes. It also isolates high-quality plasma or cosmid DNA for extraction up to 10 kilobases and yields up to 20 micrograms per preparation, the firm said.

The kit features an integrated pH indicator within the lysis buffer, which changes color to bright yellow when the lysis buffer reaches the pH level needed for DNA binding. The kit also includes a neutralization buffer, Rnase A, activation buffer, washing buffer, elution buffer, spin columns, and collection tubes. The components create a flexible kit for downstream applications, including automated fluorescent DNA sequencing and restriction enzyme digestion, Empirical added.

Sep 07, 2018

Asuragen QuantideX NGS Data Hotspot 21 RUO Kit

Asuragen announced the CE marking and launch of its QuantideX NGS DNA Hotspot 21 Kit, a targeted next-generation sequencing panel to detect variants across a multitude of tumor types. By screening for the most commonly observed variants in a simplified workflow, the research-use-only kit addresses current clinical and laboratory challenges regarding NGS testing such as long time-to-result, high assay complexiity, and lengthy data interpretation.

The assay includes the firm's cGMP manufactured, end-to-end NGS-in-a-box design, providing the reagents needed to prepare sequencing-ready libraries in as little as 24 hours. The firm's bioinformatics software examines whether enough amplifiable DNA exists. 

Sep 04, 2018

Genoptix BCR-ABL MRDx TFR Monitoring Test

Genoptix has released its BCR-ABL MRDx TFR Monitoring Test for patients with chronic myeloid leukemia being treated with Tasigna. According to the firm, the assay is the only diagnostic  test authorized by the US Food and Drug Administration for managing patients on tyrosine kinase inhibitors. 

Aug 29, 2018

Xifin LIS 5

Xifin has launched the latest version of its lab information system, the Xifin LIS 5. The software-as-a-service-based platform includes multi-specialty workflows for molecular and next-generation sequencing. It also includes universal image management, a digital pathology consultation function, and a feature to facilitate multidisciplinary care team coordination.

Updates to the system's existing NGS module provide more specimen management, user-defined workflow steps, and the ability to support multiple lab processes. The platform's enhanced clinical trials support system now provides a project-oriented workflow. An enhanced anatomic pathology module improves the speed and functionality of new specialty workflows for gynecologic cytology, urology, and GI applications. The molecular diagnostic and genomics workflows now support FISH, gene microarray, and PCR, as well as NGS pharmacogenomics testing.

Aug 28, 2018

Empirical Bioscience EB Pure PCR Purification Kit

Empirical Bioscience has launched the EB Pure PCR Purification Kit to streamline DNA purification and recover high-quality DNA in 10 minutes. The kit uses silica-based technology, binding DNA in high-salt and eluting it in a low-salt buffer without requiring organic extractions or additional precipitation steps. The kit includes binding buffer, activation buffer, elution buffer, washing buffer, spin columns, and collection tubes. In addition, the firm said it provides maximum recovery of DNA bands from 100bp to 10kb that are free of oligonucleotides, nucleotides, and polymerase, with yields exceeding 80 percent from DNA amounts of up to 20 µg.

Aug 28, 2018

Swift Biosciences Amplicon HS Panels

Swift Biosciences has announced the early-access availability of its Swift Amplicon HS Panels, a high-sensitivity targeted amplicon library preparation kit for next-generation sequencing of liquid biopsy samples, including cell-free DNA. According to the firm, the panels allow detection and validation of mutations occurring at 0.25 percent to 3 percent frequency among a background of host samples.

The first kit being made available is Swift's EGFR Pathway Panel, which covers clinically relevant oncology hotspots including EGFR T790, KRAS G12/G13, NRAS Q61, and BRAF V600. The firm is also building custom panels and aims to release a Sample_ID panel for fetal/maternal tracing with the same sensitivity and specificity capability.

The New York Times and ProPublica look into the close relationship between a startup and Memorial Sloan Kettering Cancer Center.

Yahoo News reports millions of dollars are being transferred from NIH, CDC, and other programs to pay for the housing of detained undocumented immigrant children.

In Science this week: in vitro generation of human reproductive cells, and more.

Researchers gave a handful of octopuses MDMA to find that they too act more social on the drug, Gizmodo reports.

Oct
02
Sponsored by
Roche

In the last few years several molecular testing methodologies — such as immunohistochemistry, PCR, and sequencing — have been approved by the US Food and Drug Administration to aid in the management of patients with lung cancer.  

Oct
11
Sponsored by
ArcherDX

This webinar will discuss a validation study for a next-generation sequencing (NGS) assay for hematological malignancies (e.g., acute myeloid leukemia, acute lymphocytic leukemia, myelodysplastic syndrome, and myeloproliferative neoplasms).

Nov
05
Sponsored by
Sophia Genetics

With the Next Generation Sequencing (NGS), genomes sequencing has been democratized over the last decades with the detection of genomic alterations, thus replacing Sanger sequencing.