Skip to main content
Premium Trial:

Request an Annual Quote

Desktop Genetics DTG-Seq Service

Desktop Genetics recently launched its DTG-Seq service, which combines targeted amplicon sequencing and internal bioinformatics expertise for validation of on- and off-target genome editing outcomes. To use DTG-Seq, customers send isolated genomic DNA samples to Desktop's sequencing provider, while Desktop handles steps such as primer design and amplicon library preparation. The company's bioinformatics team then analyzes raw FASTQ files and investigates the efficiency and distribution of CRISPR mutations at on- and/or off-target sites. Desktop then summarizes and delivers the analysis in graphical reports along with raw sequencing data files. The company said that it can detect CRISPR editing events at frequencies as low as 0.1 percent.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.