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Desktop Genetics DTG-Seq Service

Desktop Genetics recently launched its DTG-Seq service, which combines targeted amplicon sequencing and internal bioinformatics expertise for validation of on- and off-target genome editing outcomes. To use DTG-Seq, customers send isolated genomic DNA samples to Desktop's sequencing provider, while Desktop handles steps such as primer design and amplicon library preparation. The company's bioinformatics team then analyzes raw FASTQ files and investigates the efficiency and distribution of CRISPR mutations at on- and/or off-target sites. Desktop then summarizes and delivers the analysis in graphical reports along with raw sequencing data files. The company said that it can detect CRISPR editing events at frequencies as low as 0.1 percent.

The Scan

Follow-Up Data Requests to Biobank Participants Ineffective, Study Finds

An effort to recontact biobank enrollees for additional information reports low participation in a new BMJ Open study.

Study Finds Widespread Transmission of Resistant Bacteria in Vietnam Hospitals

A sequencing study in The Lancet Microbe finds widespread transmission of drug-resistant Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii in two Vietnam ICUs.

Novel Brain Cell Organoids Show Promise for Autism Research

University of Utah researchers report in Nature Communications on their development of brain cell organoids to study SHANK3-related autism.

Study Finds Few FDA Post-Market Regulatory Actions Backed by Research, Public Assessments

A Yale University-led team examines in The BMJ safety signals from the US FDA Adverse Event Reporting System and whether they led to regulatory action.