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Definiens' Biomarker Datafication Services for Oncology

Definiens has launched a suite of biomarker datafication services for oncology clinical development programs. These services will enable pharmaceutical and biotech companies gather comprehensive data from tissue samples that they can use to make decisions about which drug candidates to advance as well as assess the potential of companion diagnostics for patient stratification. Through the service, users gain access to data such as biomarker expression profiles, biological response to therapy and continuous biomarker readouts enabling advanced decision making and data analysis.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.