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Cyclica Ligand Express

Toronto-based company Cyclica has launched a cloud-based proteome screening platform called Ligand Express. The platform provides users access to the company's AI-assisted, structure-based molecular simulation technology. Users can submit small molecules of interest to rapidly generate unique polypharmacology profiles. These profiles consist of on- and off-target interactions that may be expected, as well as those that are unanticipated, to aid decision making. Off-target interactions can be viewed using the platform's interactive, analytical tools that enable exploration and facilitate deep insights that cannot be gained through traditional target-based approaches.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.