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Codex DNA SARS-CoV-2 Synthetic Genomes for UK and South Africa Variants

Codex DNA has released full-length synthetic genomes for the emerging SARS-CoV-2 variants B.1.1.7 and B.1.351, identified in the UK and South Africa, respectively.

The genomes are synthesized de novo on Codex DNA's BioXp 3250 system and can be used in developing vaccines, therapeutics, and diagnostics for COVID-19 research. They can be activated for use in monoclonal antibody therapy or vaccine development or serve as diagnostic controls.

The Scan

Octopus Brain Complexity Linked to MicroRNA Expansions

Investigators saw microRNA gene expansions coinciding with complex brains when they analyzed certain cephalopod transcriptomes, as they report in Science Advances.

Study Tracks Outcomes in Children Born to Zika Virus-Infected Mothers

By following pregnancy outcomes for women with RT-PCR-confirmed Zika virus infections, researchers saw in Lancet Regional Health congenital abnormalities in roughly one-third of live-born children.

Team Presents Benchmark Study of RNA Classification Tools

With more than 135 transcriptomic datasets, researchers tested two dozen coding and non-coding RNA classification tools, establishing a set of potentially misclassified transcripts, as they report in Nucleic Acids Research.

Breast Cancer Risk Related to Pathogenic BRCA1 Mutation May Be Modified by Repeats

Several variable number tandem repeats appear to impact breast cancer risk and age at diagnosis in almost 350 individuals carrying a risky Ashkenazi Jewish BRCA1 founder mutation.