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Clontech Guide-it CRISPR/Cas9 Gesicle Production System

Clontech Laboratories, a subsidiary of Takara Bio, has launched the Guide-it CRISPR/Cas9 Gesicle Production System. The kit enables delivery of CRISPR/Cas9 genome editing systems via gesicles, cell-derived nanovesicles engineered with surface glycoproteins to help bind and fuse to a broad range of cell types. Gesicles contain and deliver the Cas9 protein complexed with the guide RNA targeting the genomic site of interest. The kit includes lyophilized Xfect Transfection Reagent, gesicle packaging mixes containing coding sequences for the nanovesicle-inducing glycoprotein, Cas9 endonuclease, CherryPicker red fluorescent protein, a pre-linearized vector for cloning target sgRNA, and A/C Heterodimerizer for gesicle loading.

The Scan

Panel Recommends Pfizer-BioNTech Vaccine for Kids

CNN reports that the US Food and Drug Administration advisory panel has voted in favor of authorizing the Pfizer-BioNTech SARS-CoV-2 vaccine for children between 5 and 11 years old.

Sharing How to Make It

Merck had granted a royalty-free license for its COVID-19 treatment to the Medicines Patent Pool, according to the New York Times.

Bring it Back In

Bloomberg reports that a genetic analysis has tied a cluster of melioidosis cases in the US to a now-recalled aromatherapy spray.

Nucleic Acids Research Papers on SomaMutDB, VThunter, SCovid Databases

In Nucleic Acids Research this week: database of somatic mutations in normal tissue, viral receptor-related expression signatures, and more.