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Clontech Guide-it CRISPR/Cas9 Gesicle Production System

Clontech Laboratories, a subsidiary of Takara Bio, has launched the Guide-it CRISPR/Cas9 Gesicle Production System. The kit enables delivery of CRISPR/Cas9 genome editing systems via gesicles, cell-derived nanovesicles engineered with surface glycoproteins to help bind and fuse to a broad range of cell types. Gesicles contain and deliver the Cas9 protein complexed with the guide RNA targeting the genomic site of interest. The kit includes lyophilized Xfect Transfection Reagent, gesicle packaging mixes containing coding sequences for the nanovesicle-inducing glycoprotein, Cas9 endonuclease, CherryPicker red fluorescent protein, a pre-linearized vector for cloning target sgRNA, and A/C Heterodimerizer for gesicle loading.

The Scan

And For Adolescents

The US Food and Drug Administration has authorized the Pfizer-BioNTech SARS-CoV-2 vaccine for children between the ages of 12 and 15 years old.

Also of Concern to WHO

The Wall Street Journal reports that the World Health Organization has classified the SARS-CoV-2 variant B.1.617 as a "variant of concern."

Test for Them All

The New York Times reports on the development of combined tests for SARS-CoV-2 and other viruses like influenza.

PNAS Papers on Oral Microbiome Evolution, Snake Toxins, Transcription Factor Binding

In PNAS this week: evolution of oral microbiomes among hominids, comparative genomic analysis of snake toxins, and more.