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Clear Labs Clear Safety NGS Platform

Feb 19, 2019

Clear Labs has released a software update for its Clear Safety NGS platform, which now includes Salmonella serotyping. According to the firm, food safety professionals can now detect up to 40 unique Salmonella serotypes in an enriched sample in about 24 hours. With the update, Clear Labs said that the platform allows food manufacturers and service labs to test for the presence or absence of pathogens and serotypes at the same time. In addition, the firm noted that customers can now choose if they want to test for the disease at the genus level, species level, or the serotype level. 

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Nov 22, 2019

Biocept TRK Assay

Biocept said it has launched a new assay for detection of TRK proteins in circulating tumor cells, intended to help inform physicians of patients' NTRK fusion status, an actionable biomarker that can be used to qualify patients for treatment with TRK inhibitor therapies.

The launch brings the company's CLIA lab test menu to 20 assays, including a variety of other single-gene tests analyzed in either circulating cell-free DNA or CTCs, and a next-gen sequencing panel test for lung cancer biomarkers.

Nov 20, 2019

Thermo Fisher Scientific Applied Biosystems SeqStudio Genetic Analyzer for Human Identification

Thermo Fisher Scientific has launched the Applied Biosystems SeqStudio Genetic Analyzer for Human Identification, a capillary electrophoresis platform. The system is designed for small- to medium-sized forensic DNA and paternity laboratories. It has been validated according to Scientific Working Group on DNA Analysis Methods (SWGDAM) guidelines on several Applied Biosystems STR amplification kits. The instrument uses an integrated cartridge that combines a capillary array, polymer reservoir, and anode buffer.

Nov 19, 2019

HTG Molecular Diagnostics EdgeSeq Reveal V 2.0

HTG Molecular Diagnostics has released its HTG EdgeSeq Reveal data analysis software, version 2.0. The Tucson, Arizona-based firm said that the new software contains enhanced functionality, allowing rapid data analysis from the HTG EdgeSeq Autoimmune Panel.

Nov 15, 2019

MedGenome South Asian Research Genotyping Array (SARGAM)

MedGenome has introduced the South Asian Research Genotyping Array, which leverages MedGenome's proprietary database of 2.5 million variants unique to the South Asian population and not available in any publicly available genetic database. MedGenome will use sequence data generated in its facility in Bengaluru, India to continue to identify unique content for SARGAM, which is based on Thermo Fisher Scientific's Applied Biosystems Axiom genotyping arrays. MedGenome said that SARGAM is intended to enable discovery research involving South Asian population cohorts, and will be ideal for consumer genomics solutions like ancestry and pharmacogenomics for the South Asian population.

Nov 15, 2019

Takara Bio Cellartis Intestinal Epithelial Cells Kit

Takara Bio has launched the Cellartis Intestinal Epithelial Cells (from ChiPSC18) Kit. These small intestinal epithelial cells derived from human induced pluripotent stem cells express intestinal markers at levels comparable to that of adult small intestinal tissue. They also express drug metabolizing enzyme CYP3A4 and drug transporter PEPT1 at more physiologically relevant levels compared with Caco-2, the current gold standard of intestinal models, Takara said. Additionally, the monolayer of intestinal epithelial cells forms a functional barrier that can be used for predicting intestinal permeability. The cells provide an improved model for the study of absorption and metabolism of orally administered drugs, the company said.

Nov 15, 2019

CBR ReadyGen Pediatric Genetic Screening Service

CBR, a Los Angeles-based company specializing in newborn stem cell banking, has launched a new genetic service developed in collaboration with Sema4. ReadyGen is a genetic screening test that analyzes a child's DNA for more than 200 conditions that can affect children before the age of 10. These conditions are currently addressable through medication, dietary modification, newborn stem cell transplant, or other therapies, especially when detected early in a child's life, the company said. Parents can order ReadyGen online and all orders will be reviewed and approved by a physician to ensure they are medically appropriate for the child.

Nov 15, 2019

NuProbe VarTrace Sanger Assays

NuProbe Global has launched VarTrace Sanger assays for ultrasensitive detection and quantification of cancer mutations with variant allele frequencies down to 0.1 percent. The company specifically launched three assays covering EGFR mutations for non-small-cell lung cancer; BRAF mutations for melanoma and thyroid cancer; and FLT3, DNMT3A, IDH1, IDH2, KIT, NPM1 mutations for acute myeloid leukemia. The assays are based on the firm's proprietary blocker displacement amplification (BDA) technology, and are compatible with both cell-free DNA from blood plasma and tissue samples including formalin-fixed paraffin-embedded tissue, NuProbe said.

Nov 14, 2019

Loop Genomics Long-Read PCR Amplicon Sequencing Kit, Service

Loop Genomics has launched a new amplicon library prep kit and service for generating synthetic long sequence reads from long PCR amplicons on Illumina sequencers. The kit can be used for PCR fragments up to 3 kb in size and the service can process orders for PCR fragments up to 6 kb long.

Nov 14, 2019

Grifols AlphaID

Grifols has lunched the AlphaID, a cheek swab for use by doctors to screen patients with chronic obstructive pulmonary disease for alpha-1 antitrypsin deficiency, a rare, life-threatening genetic condition. Grifols said the swab is completely free, "from ordering to results," and leverages a US Food and Drug Administration-approved genotyping assay to screen for the 14 most prevalently reported genetic mutations associated with the condition, including the S,Z,F, and I alleles, as well as rare and null alleles. 

Nov 13, 2019

Personalis Whole-Genome Sequencing Service

Personalis has launched a new whole-genome sequencing service, extending its existing portfolio of comprehensive cancer omics tests, including targeted gene panels, exome, and transcriptome products. The company said that the new offering reflects its experience analyzing cancer samples across numerous biopharma oncology clinical trials, and takes advantage of "large-scale laboratory and data systems" developed as part of its WGS effort for the US Department of Veterans Affairs' Million Veteran Program.

Nov 08, 2019

Akoya Biosciences Motif PD-1/PD-L1 Panels

Akoya Biosciences has launched two multiplex immunofluorescence kits for profiling immuno-oncology biomarkers in the tumor microenvironment. The Motif PD-1/PD-L1 panels focus on PD-1 immune checkpoint blockade in lung cancer and melanoma. Each kit includes six immunofluorescence markers, plus nuclear counterstain, to capture the cellular interactions associated with PD-1/PD-L1 immune suppression. The kits are optimized for high-throughput staining on commonly used autostainers and rapid scanning on the Vectra Polaris multiplexed imaging system.

Nov 07, 2019

Ceres Nanosciences Nanotrap Virus Capture Kit

Ceres Nanosciences has launched the Nanotrap Virus Capture Kit, which concentrates whole virus particles from complex biological matrices resulting in high-quality input material for a range of downstream analytical methods such as multiplex nucleic acid, protein, and infectivity assays. The company said that it has data demonstrating the kit's compatibility with multiple commercial nucleic acid kits for influenza virus samples, as well as an application note demonstrating use of the technology to improve the detection of Zika virus in urine samples.

Nov 07, 2019

Ultivue UltiMapper Multiplex Immunofluorescence Kits

Ultivue has expanded its UltiMapper Multiplex Immunofluorescence Kit portfolio with a T-reg and MDSC kit. The UltiMapper I/O T-reg kit identifies regulatory T cells and cytotoxic T cells within the tumor context and allows for the phenotyping of activated double-positive T cells. The UltiMapper I/O MDSC kit enables the identification and characterization of myeloid-derived suppressor cells and allows researchers to differentiate M-MDSC from PMN-MDSC phenotypes. The new kits feature high-throughput whole-slide imaging using the same conventional IHC equipment and workflows as the previously released UltiMapper I/O PD-L1, UltiMapper I/O PD-1, UltiMapper I/O T-act, and UltiMapper I/O APC kits, the company said.

Nov 07, 2019

Qiagen QiaSeq Multimodal Panels

Qiagen has launched a new workflow, called QiaSeq Multimodal Panels, for the simultaneous preparation of DNA and RNA libraries for next-generation sequencing. The panels require an input as low as 10 nanograms of total nucleic acid and the workflow takes about nine hours. Both libraries are generated from the same sample and allow for the analysis of DNA variants, RNA fusions, and gene expression levels.

Nov 07, 2019

Lifebit Biotech CloudOS

Lifebit Biotech has introduced Lifebit CloudOS, a cloud-native, federated genomics operating system that supersedes the beta-release Lifebit Deploit from 2017. CloudOS works as a managed service of individual clouds or high-performance computing centers to support analysis of bioinformatics data across sites and institutions. The company said that this system automates analysis and the application of machine learning, removing a major barrier to precision medicine, population, genomics, drug discovery, and direct-to-consumer genetics progress. 

The General Data Protection Regulation has slowed some data sharing with non-European researchers as they find ways to comply with the law, ScienceInsider reports.

A bioethicist from Abertay University uses a utilitarian approach to justify genetically modifying the human germline, the BBC reports.

The US has upgraded its network of public health labs to provide whole-genome sequencing to track antibiotic-resistant bacteria, Quartz reports.

In Science this week: approach to visualize 3D genome structure in single cells, RNA interference knockdown screens to examine genetic origins of beetle horns and insect wings,  and more.