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Children's Hospital Los Angeles OncoKids

Children's Hospital Los Angeles has launched OncoKids, a next-generation sequencing-based panel that detects mutations, gene amplification, and gene fusions for a full range of pediatric cancers including leukemias, bone and soft tissue tumors, and brain tumors. It only requires a small amount of DNA and RNA (20ng) isolated from fresh, frozen, or formalin-fixed paraffin-embedded tissue. The test was developed in collaboration with Thermo Fisher Scientific and uses the Ion Torrent S5 sequencing platform and Ion AmpliSeq technology.

The Scan

Genetic Testing Approach Explores Origins of Blastocyst Aneuploidy

Investigators in AJHG distinguish between aneuploidy events related to meiotic missegregation in haploid cells and those involving post-zygotic mitotic errors and mosaicism.

Study Looks at Parent Uncertainties After Children's Severe Combined Immunodeficiency Diagnoses

A qualitative study in EJHG looks at personal, practical, scientific, and existential uncertainties in parents as their children go through SCID diagnoses, treatment, and post-treatment stages.

Antimicrobial Resistance Study Highlights Key Protein Domains

By screening diverse versions of an outer membrane porin protein in Vibrio cholerae, researchers in PLOS Genetics flagged protein domain regions influencing antimicrobial resistance.

Latent HIV Found in White Blood Cells of Individuals on Long-Term Treatments

Researchers in Nature Microbiology find HIV genetic material in monocyte white blood cells and in macrophages that differentiated from them in individuals on HIV-suppressive treatment.