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Centogene CentoMD 3.0

Centogene has launched CentoMD 3.0, an updated version of the company's identified variant database. It includes data from more than 74,000 diagnosed individuals, more than 22,000 genes curated in detail, and the clinical significance of these variants evaluated by strict guidelines. The new release gives the medical community access to an advanced Phenotype-to-Genotype module that enables symptom-based queries and returns candidate genes as well as associated underlying the symptoms of interest. It also can work as a Genotype-to-Phenotype module to provide an interactive search interface to select and filter through genes, transcripts, and variants.

The Scan

Machine Learning Helps ID Molecular Mechanisms of Pancreatic Islet Beta Cell Subtypes in Type 2 Diabetes

The approach helps overcome limitations of previous studies that had investigated the molecular mechanisms of pancreatic islet beta cells, the authors write in their Nature Genetics paper.

Culture-Based Methods, Shotgun Sequencing Reveal Transmission of Bifidobacterium Strains From Mothers to Infants

In a Nature Communications study, culture-based approaches along with shotgun sequencing give a better picture of the microbial strains transmitted from mothers to infants.

Microbial Communities Can Help Trees Adapt to Changing Climates

Tree seedlings that were inoculated with microbes from dry, warm, or cold sites could better survive drought, heat, and cold stress, according to a study in Science.

A Combination of Genetics and Environment Causes Cleft Lip

In a study published in Nature Communications, researchers investigate what combination of genetic and environmental factors come into play to cause cleft lip/palate.