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Cellecta Single-Module CRISPR Human Genome-Wide 80K Knockout Library

Cellecta has launched the single-module CRISPR Human Genome-Wide 80K Knockout library. The new library includes 4 guide RNAs per gene and is half the size of the company's current three-module CRISPR 150K Human Genome-Wide Knockout Library. The reduced library size enables researcher to study how cells respond to the disruption of each gene across the entire human genome in a single screening experiment. This aids the researchers ability to identify genetic elements that are functionally important in biological responses and identify new therapeutic targets.

The Scan

Study Tracks Off-Target Gene Edits Linked to Epigenetic Features

Using machine learning, researchers characterize in BMC Genomics the potential off-target effects of 19 computed or experimentally determined epigenetic features during CRISPR-Cas9 editing.

Coronary Artery Disease Risk Loci, Candidate Genes Identified in GWAS Meta-Analysis

A GWAS in Nature Genetics of nearly 1.4 million coronary artery disease cases and controls focused in on more than 200 candidate causal genes, including the cell motility-related myosin gene MYO9B.

Multiple Sclerosis Contributors Found in Proteome-Wide Association Study

With a combination of genome-wide association and brain proteome data, researchers in the Annals of Clinical and Translational Neurology tracked down dozens of potential multiple sclerosis risk proteins.

Quality Improvement Study Compares Molecular Tumor Boards, Central Consensus Recommendations

With 50 simulated cancer cases, researchers in JAMA Network Open compared molecular tumor board recommendations with central consensus plans at a dozen centers in Japan.