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Cellecta Single-Module CRISPR Human Genome-Wide 80K Knockout Library

Cellecta has launched the single-module CRISPR Human Genome-Wide 80K Knockout library. The new library includes 4 guide RNAs per gene and is half the size of the company's current three-module CRISPR 150K Human Genome-Wide Knockout Library. The reduced library size enables researcher to study how cells respond to the disruption of each gene across the entire human genome in a single screening experiment. This aids the researchers ability to identify genetic elements that are functionally important in biological responses and identify new therapeutic targets.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.