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Cartagenia Bench Lab 5.0

Agilent Technologies has released the Cartagenia Bench Lab 5.0. This version of the software includes new capabilities for somatic variant classification, review, curation, and reporting, the company said. The updated variant curation tools enable labs to build internal knowledgebases that contain predictive, prognostic, diagnostic, and functional evidence for variants. It accesses tumor type ontology and variant information from curated and public databases to help labs efficiently implement their variant assessment standard operating procedure and more effectively filter variants. The software provides direct access to more than 100 curated databases including CIViC, COSMIC, N-of-One, OncoMD, and CollabRx.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.