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CareDx European HLA Typing Service

CareDx has launched a research-use-only HLA typing service for customers in Europe out of its next-generation sequencing lab in Stockholm. The CareDx HLA typing service is powered by AlloSeq Tx17 and uses high-resolution hybrid-capture technology to yield a fast turnaround time with no long-range PCR inefficiencies. CareDx said that AlloSeq Tx17 provides over 50 percent more gene content than other commercial NGS solutions, including 11 classical HLA loci as well as HLA-E, -F, -G, -H, MICA, and MICB. A company spokesperson said that the service will be available to customers in the US later this year.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.