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Cambridge Isotope Laboratories Mouse Express NeuCode

Cambridge Isotope Laboratories has launched Mouse Express NeuCode, a mouse feed with various combinations of labeled Lys isotopologues for MS proteomics studies. The product will increase the multiplexing potential for traditional SILAC quantitative experiments involving neuron encoding. It uses isotopologues of lysine for multiplexed relative quantification of proteins by high-resolution MS. NeuCode also drastically cuts down on labeling time compared to SILAM and allows detection of a greater number of peptides than SILAC, the company said. The product is available in one-week or three-week quantities, and each kit contains enough feed for three mice.

The Scan

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.

SpliceVault Portal Provides Look at RNA Splicing Changes Linked to Genetic Variants

The portal, described in Nature Genetics, houses variant-related messenger RNA splicing insights drawn from RNA sequencing data in nearly 335,700 samples — a set known as the 300K-RNA resource.

Automated Sequencing Pipeline Appears to Allow Rapid SARS-CoV-2 Lineage Detection in Nevada Study

Researchers in the Journal of Molecular Diagnostics describe and assess a Clear Labs Dx automated workflow, sequencing, and bioinformatic analysis method for quickly identifying SARS-CoV-2 lineages.

UK Team Presents Genetic, Epigenetic Sequencing Method

Using enzymatic DNA preparation steps, researchers in Nature Biotechnology develop a strategy for sequencing DNA, along with 5-methylcytosine and 5-hydroxymethylcytosine, on existing sequencers.