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Biogazelle's microRNA Quantification Service

Jun 12, 2015

Biogazelle is now offering massively parallel sequencing to quantify microRNAs in compromised samples characterized by degraded RNA or low output amounts. The service offering comibnes optimal library preparation and purification, so that sequencing reads are actually spent on mature microRNAs, and not on undesirable contaminants such as ribosomal and other long RNA fragments, the company said. Further, raw data reads are processed and analyzed using Ant, Biogazelle's custom small RNA sequencing analysis pipeline that is part of Cobra, its RNA sequencing data-analysis platform.

Participants of the program will be able to send a representative sample that will be sequenced at very high coverage in order to determine the biomarker potential and optimal sequencing depth for future studies, Biogazelle said.

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May 28, 2020

Analytik Jena Biometra TRobot II and qTOWER³ Auto Thermal Cyclers

Jena, Germany-based life science firm Analytik Jena has introduced two new thermal cyclers. The Biometra TRobot II is a small footprint PCR module that can be used to save space in a robotic setup, while the qTOWER³ Auto is a qPCR thermal cycler useful for fully automated qPCR applications.

May 28, 2020

Swift Biosciences Normalase Amplicon Panel SARS-CoV-2 Kit

Swift Biosciences has released a new sample preparation kit for low viral titer SARS-CoV-2 specimens.

The Swift Normalase Amplicon Panel SARS-CoV-2 kit targets the full coronavirus genome in a single-tube reaction. The two round PCR workflow takes as little as two hours and produces multiplexed, sequencing-ready libraries.

The kit is intended for use in research or pathogen surveillance.

May 27, 2020

Thermo Fisher Scientific Orbitrap Exploris Mass Spectrometers, Proteome Discoverer 2.5 Software, Xcalibur 4.4 Software

Thermo Fisher Scientific has released the Thermo Scientific Orbitrap Exploris 240 and 120 mass spectrometers. The Exploris 240 is designed for researchers working in proteomics, metabolomics, biopharmaceutical characterization, and small-molecule analysis. It promises discovery and identification with increased accuracy and offers operational simplicity and streamlined time-to-result. The system delivers mass accuracy, sensitivity, and resolving power across a wide dynamic range. It offers positive/negative-mode switching for comprehensive sample coverage and fast scan speeds.

The Exploris 120 offers internal calibration for consistent data quality and decision making. It features fast scanning modes and rapid polarity switching for comprehensive sample coverage and increased productivity.

In addition, the company launched the Thermo Scientific Proteome Discoverer 2.5 software for higher-confidence peptide identification, more accurate quantification, and higher-throughput data analysis of proteomics data. It uses deep learning to more accurately predict fragmentation mass spectra, facilitated by a Prosit-derived neural network licensed from bioinformatics firm and collaborator MSAID. It also provides more confident results in applications that require large search spaces, such as human leukocyte antigen (HLA) or metaproteomic analyses. In addition, the new release includes an enrichment service that helps provide biological meaning for differential analyses and support of targeted workflows. It also has tools to help deploy Thermo Scientific SureQuant Targeted Mass Spectrometry Assay Kits and custom SureQuant IS-triggered acquisition assays in new proteomics labs.

The company also launched the Thermo Scientific Xcalibur 4.4 software, which brings the AcquireX intelligent data acquisition workflow to Thermo Scientific Orbitrap Exploris mass spec platform users. It enables the fully automated collection of high-quality MS/MS data on components of interest in a sample and reduces manual input and the need for repeat runs.

May 22, 2020

Genedata Imagence 2.0

Genedata has released Genedata Imagence 2.0, the latest version of its enterprise software high-content screening image analysis. The new version offers full end-to-end automation, reducing the time spent on image analysis by an order of magnitude. It enables the analysis of complex phenotypic assay formats without extensive expert input, and the transfer of gained knowledge to new experimental setups. It has also been further optimized for use of distributed computing resources. In particular, the parallelization of image analysis steps results in massive time and cost savings, the company said. Similar to other components of the Genedata Biopharma Platform, the new software can be deployed using on-demand cloud computing service providers like Amazon Web Services.

May 20, 2020

10x Genomics Targeted Gene Expression Solution

10x Genomics has launched its Targeted Gene Expression Solution for single-cell sequencing.

The firm is offering kits for predesigned gene panels relevant to cancer, immunology, neuroscience, and drug targeting applications, with the option for customization.

May 19, 2020

Aalto Bio Reagents Recombinant SARS-CoV-2 Spike Proteins

Dublin-based Aalto Bio Reagents has released a range of recombinant SARS-CoV-2 spike (S) proteins for diagnostic test manufacturers, vaccine developers, and researchers globally. The S protein is the main antigenic component that is responsible for inducing host immune responses and neutralizing antibodies, making it the principal focus of therapeutic and vaccine design for COVID-19. When used solely or in combination with Aalto's new insect-derived nucleocapsid protein (N), the company's S1-S2 chimeric glycoprotein has demonstrated excellent reactivity in ELISA for the detection of IgA, IgG and IgM antibodies against SARS-CoV-2, the company said.

May 19, 2020

Thermo Fisher Scientific Invitrogen RiboMinus Bacteria 2.0 Transcriptome Isolation Kit

Thermo Fisher Scientific has released the Invitrogen RiboMinus Bacteria 2.0 Transcriptome Isolation Kit for the probe-based depletion of ribosomal RNA from bacteria. The kit, which can be automated on Thermo Fisher KingFisher instruments, uses a novel magnetic bead-based purification technology to selectively deplete rRNA transcripts from total RNA. It now includes 5S targets and more than 100 probe designs to yield improved rRNA depletion and can be utilized with RNA from a wide variety of species.

May 19, 2020

Oxford Immunotec T-Spot Discovery SARS-CoV-2 RUO Kit

Oxford Immunotec Global has launched the T-Spot Discovery SARS-CoV-2 test kit for research use only. The kit builds on its experience with tuberculosis diagnosis and the assessment of the immune response to cytomegalovirus infections in transplant patients. Using the company's established T-Spot technology, the kit interrogates the immune system's T-cell response and will enable research into the measurement of the strength of that response to SARS-CoV-2, Oxford Immunotec said.

May 14, 2020

EnGenome eVai Variant Interpretation/Genomenon Mastermind Genomic Search Engine

Genomenon's Mastermind Genomic Search Engine has been integrated into the eVai Variant Interpretation platform from EnGenome, Genomenon said. eVai users can now preview the number of published articles related to their search and easily link out to view the evidence in Mastermind. By combining artificial intelligence with ACMG-AMP guidelines, eVai classifies and prioritizes every genomic variant for pathogenicity, suggesting all possible related genetic diagnoses. Mastermind has indexed more than 7.5 million full-text articles and 1.5 million supplemental data sets, and covers more than 6.1 million variants found in the medical literature.

May 14, 2020

Biocept Target Selector BRAF RUO Kits

Biocept has launched a Target Selector research-use-only molecular assay for the detection of BRAF mutations in both formalin-fixed, paraffin-embedded samples and blood samples. The kits use the company's Switch-Blocker technology to enrich the specimen for mutations of interest, resulting in ultra-high assay sensitivity and specificity. Biocept said that in general, its Target Selector kits can detect mutations of interest in circulating tumor DNA at a level of one mutant copy in 10,000 wildtype molecules. The assays can be used with a variety of analytical platforms including qPCR, Sanger sequencing, next generation sequencing, microarrays, and mass spectrometry. The new BRAF kit complements the company's previously launched EGFR mutation-detection assay.

May 13, 2020

ZeptoMetrix NATSARS(CoV-2) Quality Controls

ZeptoMetrix has launched its ready-to-use NATSARS(CoV-2) molecular quality controls, including its NATtrol SARS-CoV-2 Positive Control and NATtrol SARS-CoV-2 Negative Control. The firm said the tools are formulated with purified intact viral particles chemically modified to render them non-infectious and refrigerator stable. ZeptoMetrix said the products will provide laboratories external run controls to help establish the reliability of COVID-19 testing.

May 12, 2020

Beckman Coulter Life Sciences RNAdvance Viral XP

Beckman Coulter Life Sciences announced the launch of its new RNA extraction kit, RNAdvance Viral XP. The kit is validated for use in infectious disease and real-time PCR virus research and is intended for use in high-throughput settings to extract viral RNA from swab samples, the firm said. After it has been extracted, the RNA is used in qRT-PCR kits to determine whether the virus is present. Danaher subsidiary Beckman Coulter worked with next-generation sequencing company iRepertoire to develop the kit's method, which iRepertoire then independently validated. 

May 12, 2020

Roche KAPA Target Enrichment Portfolio

Roche launched its new KAPA Target Enrichment product portfolio, which includes both exome and custom target enrichment solutions for sequencing. The KAPA HyperExome is a whole-exome research panel with improved performance compared to the existing SeqCap portfolio that targets the GRCh38/hg38 geome assembly. Roche's HyperDesign tool allows for the creation of custom target enrichment designs using the KAPA HyperChoice probes. The target enrichment portfolio will increase sequencing efficiency, the company said. The new probes will replace the SeqCap product portfolio, which is expected to be discontinued in the first quarter of 2022. 

May 11, 2020

LGC SARS-CoV-2 Verification Panel and Reference Materials; Charité ValuPanel Assay Reagents

LGC Seracare has launched new versions of its AccuPlex Verification Panel and Reference Material Kit for SARS-CoV-2 testing. The previous versions contained negative control material targeting the human RNase P gene and positive control material for the viral ORF1a, RdRp, E, and N gene consensus sequences targeted in the US Centers for Disease Control and Prevention and World Health Organization assays. They have now been expanded to include the S gene region of the virus. 

In addition, LGC Biosearch Technologies has launched new assays in its ValuPanel line. The Charité 2019-nCoV BHQ and BBQ-650 ValuPanel Reagent sets use oligonucleotide sequencedesigned by the German Center for Infection Research (DZIF) at Charité. The firm also now offers US CDC 2019-nCoV BHQ ValuPanel Reagents sets, and continues to offer the 2019-nCoV CDC-qualified Probe and Primer Kits for SARS-CoV-2.

May 08, 2020

Samplix Xdrop Services

Danish company Samplix has launched a comprehensive service program granting laboratories access to its Xdrop technology for complex genomic research including gap closing, sequencing of repeat elements, viral insertion site detection, revealing unintended CRISPR edits, and more. Xdrop enriches genomic regions longer than 100 kb from as little as 1 ng of human genomic DNA and with single-molecule resolution. It requires knowledge of only a short sequence within or flanking the target region for efficient target selection. Following targeted selection, multiple displacement amplification is applied to single DNA molecules compartmentalized in droplets. This ensures unbiased amplification of large DNA fragments that are representative of the target variation in the original sample. The output is ready for any short-read or long-read sequencing platform, the company said.

The first reported coronavirus cases in Europe and the US might not be related to the subsequent outbreaks in those areas, according to the New York Times.

According to NPR, there's a growing shortage of machines to run SARS-CoV-2 tests.

The Wall Street Journal and Kaiser Health News report that antibody testing for SARS-CoV-2 has led to further confusion.

In Nature this week: the largest known collection of human genetic variants, and more.

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NanoString

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Ovation

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Illumina

In this webinar, Dr. Charlie Johnson, founder of the Texas A&M AgriLife Genomics and Bioinformatics Service, will share how his team is utilizing Illumina’s DRAGEN informatics platform in its high-throughput agrigenomics research program. 

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LGC SeraCare Life Sciences

Cancer immunotherapy is an exciting new advance for the successful treatment of many forms of metastatic cancer.