Skip to main content
Premium Trial:

Request an Annual Quote

Biogazelle HTPathwaySeq and HTTargetSeq

Belgian CRO Biogazelle has launhced HTPathwaySeq and HTTargetSeq RNA sequencing and data-analysis services. HTPathwaySeq generates in-depth information on drug mode of action, highlights molecular similarities between compounds, and reveals potential compound-induced toxicities, all of which help provide critical data for candidate prioritization in drug development. HTTargetSeq supports the development of RNA-targeting oligonucleotides such as short interfering RNAs (siRNA) and antisense oligonucleotides (ASO). The service accurately identifies off-target genes, which the company noted is important for the anticipation of safety issues and potential repurposing of off-target genes as novel therapeutic targets. Both services are performed directly on cell lysates from 96-well culture plates, and data interpretation results are shared through Savana, Biogazelle’s proprietary visualization app.
The Scan

Wolf Howl Responses Offer Look at Vocal Behavior-Related Selection in Dogs

In dozens of domestic dogs listening to wolf vocalizations, researchers in Communication Biology see responses varying with age, sex, reproductive status, and a breed's evolutionary distance from wolves.

Facial Imaging-Based Genetic Diagnoses Appears to Get Boost With Three-Dimensional Approach

With data for more than 1,900 individuals affected by a range of genetic conditions, researchers compared facial phenotype-based diagnoses informed by 2D or 3D images in the European Journal of Human Genetics.

Survey Suggests Multigene Cancer Panel VUS Reporting May Vary Across Genetic Counselors

Investigators surveyed dozens of genetic counselors working in clinical or laboratory settings, uncovering attitudes around VUS reporting after multigene cancer panel testing in the Journal of Genetic Counseling.

Study Points to Tuberculosis Protection by Gaucher Disease Mutation

A mutation linked to Gaucher disease in the Ashkenazi Jewish population appears to boost Mycobacterium tuberculosis resistance in a zebrafish model of the lysosomal storage condition, a new PNAS study finds.