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Bio-Rad Droplet Digital PCR-Based Assays

Bio-Rad Laboratories has launched droplet digital PCR Genome Edit Detection assays, which can characterize edits generated by CRISPR-Cas9 or other genome editing tools. The assays use ddPCR technology which increases the signal-to-noise ratio, allowing users to quantify extremely rare edits, even those with frequencies of 0.5 percent and from as little as 5 nanograms of genomic DNA. Users can expect to obtain results within one day.

The Scan

Positive Framing of Genetic Studies Can Spark Mistrust Among Underrepresented Groups

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants.

Small Study of Gene Editing to Treat Sickle Cell Disease

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms.

Gut Microbiome Changes Appear in Infants Before They Develop Eczema, Study Finds

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema.

Acute Myeloid Leukemia Treatment Specificity Enhanced With Stem Cell Editing

A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy.