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Berkeley Lights OptoSeq 3' mRNA Library Kit

Berkeley Lights has launched its OptoSeq 3' mRNA Library kit, which allows users to directly link phenotype to genotype. The kit inculdes reagents, primers, probes, and enzymes to prepare and label individual cells for cDNA sequencing. 

According to the firm, customers can use the library prep kit to capture and link genomic information to single-cell phenotypic data in order to learn more about cellular behavior and ramp up discovery, development, and production of cell-based products. 

The Scan

Drug Response Variants May Be Distinct in Somatic, Germline Samples

Based on variants from across 21 drug response genes, researchers in The Pharmacogenomics Journal suspect that tumor-only DNA sequences may miss drug response clues found in the germline.

Breast Cancer Risk Gene Candidates Found by Multi-Ancestry Low-Frequency Variant Analysis

Researchers narrowed in on new and known risk gene candidates with variant profiles for almost 83,500 individuals with breast cancer and 59,199 unaffected controls in Genome Medicine.

Health-Related Quality of Life Gets Boost After Microbiome-Based Treatment for Recurrent C. Diff

A secondary analysis of Phase 3 clinical trial data in JAMA Network Open suggests an investigational oral microbiome-based drug may lead to enhanced quality of life measures.

Study Follows Consequences of Early Confirmatory Trials for Accelerated Approval Indications

Time to traditional approval or withdrawal was shorter when confirmatory trials started prior to accelerated approval, though overall regulatory outcomes remained similar, a JAMA study finds.